Results 51 to 60 of about 47,911 (258)

Conformational Change in a Four‐Tetrad DNA G‐Quadruplex upon Intercalation of a Small‐Molecule Ligand PyDH2

Angewandte Chemie International Edition, EarlyView.
An exception or the rule? This work represents a second observation, and the first crystallographic evidence, of true intercalation of a small‐molecule ligand (here, bisquinolinium PyDH2) into an antiparallel G‐quadruplex (G4) DNA fold. Abstract G‐quadruplexes (G4s) are non‐canonical DNA structures implicated in a number of biological processes.
Kailey N. Martin, Gwendolyn Lam, Oksana Reznichenko, Kyle E. Brunner, Michael J. Zdilla, Sawyer E. McCarthy, Anton Granzhan, Liliya A. Yatsunyk   +7 more
wiley   +1 more source

N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena

Nucleic Acids Research, 2017
DNA N6-methyladenine (6mA) is newly rediscovered as a potential epigenetic mark across a more diverse range of eukaryotes than previously realized. As a unicellular model organism, Tetrahymena thermophila is among the first eukaryotes reported to contain
Yuanyuan Wang, Xiao Chen, Yalan Sheng, Yifan Liu, Shan Gao   +4 more
semanticscholar   +1 more source

Genome-wide analysis of the phosphoinositide kinome from two ciliates reveals novel evolutionary links for phosphoinositide kinases in eukaryotic cells. [PDF]

PLoS ONE, 2013
BACKGROUND: The complexity of phosphoinositide signaling in higher eukaryotes is partly due to expansion of specific families and types of phosphoinositide kinases (PIKs) that can generate all phosphoinositides via multiple routes.
George Leondaritis, John Siokos, Irini Skaripa, Dia Galanopoulou   +3 more
doaj   +1 more source

Transcriptional Regulation of Gene Expression in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1990
The only well-characterized study of gene expression in Tetrahymena thermophila (1) demonstrates that the temperature dependent expression of the Ser H3 gene is regulated at the level of mRNA stability.
Gorovsky, Martin A., Karrer, Kathleen M., Stargell, Laurie A.   +2 more
core   +1 more source

Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents

Chemistry &Biodiversity, EarlyView.
ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay, Alfred Muller, Sage Singh, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji   +5 more
wiley   +1 more source

N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA

Genome Biology, 2018
N6-methyldeoxyadenosine (6mA or m6dA) was shown more than 40 years ago in simple eukaryotes. Recent studies revealed the presence of 6mA in more prevalent eukaryotes, even in vertebrates. However, functional characterizations have been limited.
Guan-Zheng Luo, Ziyang Hao, Liangzhi Luo, Mingren Shen, Daniela Sparvoli, Yuqing Zheng, Zijie Zhang, X. Weng, Kai Chen, Q. Cui, A. Turkewitz, Chuan He   +11 more
semanticscholar   +1 more source

Tetrahymena RIB72A and RIB72B are microtubule inner proteins in the ciliary doublet microtubules

bioRxiv, 2018
Doublet and triplet microtubules are essential and highly stable core structures of centrioles, basal bodies, cilia and flagella. In contrast to dynamic cytoplasmic microtubules, their luminal surface is coated with regularly arranged Microtubule Inner ...
Daniel Stoddard, Ying Zhao, Brian A Bayless, L. Gui, Panagiota Louka, Drashti Dave, Swati Suryawanshi, R. Tomasi, P. Dupuis‐Williams, C. Baroud, J. Gaertig, M. Winey, D. Nicastro   +12 more
semanticscholar   +1 more source

Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetrahymena thermophila

BMC Cell Biology, 2010
Background Programmed nuclear death (PND), which is also referred to as nuclear apoptosis, is a remarkable process that occurs in ciliates during sexual reproduction (conjugation). In Tetrahymena thermophila, when the new macronucleus differentiates, the
Endoh Hiroshi, Akematsu Takahiko
doaj   +1 more source

Understanding the errors of SHAPE-directed RNA structure modeling [PDF]

, 2011
Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms. Recent tests have shown that selective 2'-hydroxyl acylation by primer extension (SHAPE) can give near-zero error rates (0-2%) in modeling the helices of RNA secondary structure. Here,
arxiv   +1 more source

Position Effect Takes Precedence Over Target Sequence in Determination of Adenine Methylation Patterns in the Nuclear Genome of a Eukaryote, \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1998
Approximately 0.8% of the adenine residues in the macronuclear DNA of the ciliated protozoan Tetrahymena thermophila are modified to N6-methyladenine. DNA methylation is site specific and the pattern of methylation is constant between clonal cell lines ...
Karrer, Kathleen M., Van Nuland, Teresa A.   +1 more
core   +1 more source