Results 61 to 70 of about 47,911 (258)

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Progeny of Germ Line Knockouts of \u3cem\u3eASI2\u3c/em\u3e, a Gene Encoding a Putative Signal Transduction Receptor in \u3cem\u3eTetrahymena Thermophila\u3c/em\u3e, Fail to Make the Transition from Sexual Reproduction to Vegetative Growth [PDF]

, 2006
The ciliated protozoan Tetrahymena has two nuclei: a germ line micronucleus and a somatic macronucleus. The transcriptionally active macronucleus has about 50 copies of each chromosome.
Cole, Eric S., Karrer, Kathleen M., Li, Shuqiang, Udani, Rupa A., Yin, Lihui   +4 more
core   +1 more source

The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice

Andrology, EarlyView.
Abstract Background RIBC1 (RIB43A domain with coiled‐coils 1) and RIBC2 (RIB43A domain with coiled‐coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unicellular organisms. Cryo‐electron microscopy and artificial intelligence studies showed that RIBC1 and RIBC2 are microtubule inner proteins (MIPs ...
Kento Katsuma, Keisuke Shimada, Shingo Tonai, Daisuke Mashiko, Rie Iida‐Norita, Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +7 more
wiley   +1 more source

Distinct functional roles of β-tubulin isotypes in microtubule arrays of Tetrahymena thermophila, a model single-celled organism.

PLoS ONE, 2012
BackgroundThe multi-tubulin hypothesis proposes that each tubulin isotype performs a unique role, or subset of roles, in the universe of microtubule function(s).
Sandra Pucciarelli, Patrizia Ballarini, Daniela Sparvoli, Sabrina Barchetta, Ting Yu, H William Detrich, Cristina Miceli   +6 more
doaj   +1 more source

Tandemly repeated C-C-C-C-A-A hexanucleotide of Tetrahymena rDNA is present elsewhere in the genome and may be related to the alteration of the somatic genome. [PDF]

, 1981
The ribosomal RNA genes of the Tetrahymena macronucleus exist as extrachromosomal, linear molecules. The termini of these molecules have been shown to contain the tandemly repeated hexanucleotide (C-C-C-C-A-A)n.
Blackburn, E, Gall, J, Yao, MC
core  

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Abal, Andersen, Avidor-Reiss, Azimzadeh, Badano, Bakowska, Balczon, Baron, Basmussen, Basto, Beisson, Berbari, Blachon, Bobinnec, Bobinnec, Broadhead, Brown, Bruns, Chad G. Pearson, Cheeseman, Culver, Dammermann, Dammermann, Daniel P.S. Osborn, Dupuis-Williams, Dutcher, Dutcher, Dutcher, Eddé, Eggenschwiler, Essner, Fry, Gaertig, Garreau de Loubresse, Gerdes, Graser, Gundersen, Hai, Hames, Hentschel, Hildebrandt, Hiraki, Jerka-Dziadosz, Kaczanowski, Keller, Keller, Kilburn, Kirkham, Kochanski, Le Clech, Leidel, Leidel, Leidel, Li, Liu, Mark Winey, Marshall, Marshall, Martinez-Campos, Matsuura, Million, Mottier-Pavie, Nakazawa, Nanney, Neuhauss, Orias, Paoletti, Pearson, Pearson, Pelletier, Peterkin, Philip L. Beales, Piperno, Rodrigues-Martins, Salisbury, Shang, Shang, Stemm-Wolf, Strnad, Thomas H. Giddings, Tobin, Tobin, Vladar, Westerfield, Wilkinson, Williams, Wloga, Woodland   +87 more
core   +2 more sources

NEK2 Control of Esophageal Squamous Cell Carcinoma Growth Based on Circadian Oscillation

Cancer Science, Volume 116, Issue 5, Page 1282-1294, May 2025.
Our findings position NEK2 as a time‐dependent oncogene and a potential biomarker in ESCC, highlighting its role in both tumorigenesis and the circadian rhythm. ABSTRACT Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy known for its aggressive nature and unfavorable outcomes.
Boning Zeng, Chao Sun, Nan Li, Qiuling Chen, Manni Rao, Kai Li, Xiaodi Liu, Shouxia Xie, Jiwu Cheng, Shaoxiang Wang, Xiao Wang   +10 more
wiley   +1 more source

Diverse Sequences within Tlr Elements Target Programmed DNA Elimination in \u3cem\u3eTetrahymena Thermophila\u3c/em\u3e [PDF]

, 2003
Tlr elements are a novel family of ~30 putative mobile genetic elements that are confined to the germ line micronuclear genome in Tetrahymena thermophila.
Karrer, Kathleen M., Wuitschick, Jeffrey D.   +1 more
core   +1 more source

Establishing a High-Throughput Locomotion Tracking Method for Multiple Biological Assessments in Tetrahymena

Cells, 2022
Protozoa are eukaryotic, unicellular microorganisms that have an important ecological role, are easy to handle, and grow rapidly, which makes them suitable for ecotoxicity assessment. Previous methods for locomotion tracking in protozoa are largely based
Michael Edbert Suryanto, Ross D. Vasquez, Marri Jmelou M. Roldan, Kelvin H. -C. Chen, Jong-Chin Huang, Chung-Der Hsiao, Che-Chia Tsao   +6 more
doaj   +1 more source

Development of a Real‐Time PCR Assay for Noninvasive Detection of Miamiensis avidus in Olive Flounder Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Miamiensis avidus (syn. Philasterides dicentrarchi) leads to high mortality and economic losses in olive flounder (Paralichthys olivaceus) aquaculture. In this study, we developed a real‐time PCR assay targeting the cytochrome c oxidase subunit I (cox1) gene of M. avidus to sensitively detect and quantify the parasite in seawater.
Jin‐Young Kim, Su‐Mi Shin, Se Ryun Kwon, Sung‐Ju Jung   +3 more
wiley   +1 more source