Genetics and Epigenetics of Mating Type Determination in Paramecium and Tetrahymena.
Annual Review of Microbiology, 2017 While sex is an ancient and highly conserved eukaryotic invention, self-incompatibility systems such as mating types or sexes appear to be derived limitations that show considerable evolutionary plasticity.
E. Orias, D. Singh, E. Meyer
semanticscholar +1 more source
1+1 = 3: a fusion of 2 enzymes in the methionine salvage pathway of Tetrahymena thermophila creates a trifunctional enzyme that catalyzes 3 steps in the pathway. [PDF]
PLoS Genetics, 2009 The methionine salvage pathway is responsible for regenerating methionine from its derivative, methylthioadenosine. The complete set of enzymes of the methionine pathway has been previously described in bacteria.
Hannah M W Salim +2 more
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\u3cem\u3eASI1\u3c/em\u3e, a Gene Encoding a Novel Leucine Zipper Protein, Is Induced during Development of the Macronucleus in \u3cem\u3eTetrahymena\u3c/em\u3e [PDF]
, 2002 Sexual reproduction in the ciliate Tetrahymena follows a complex developmental program involving the sequential regulation of dozens of genes. Genes that are up-regulated during post-zygotic development in Tetrahymena were isolated by subtractive ...
Karrer, Kathleen M., Udani, Rupa A
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Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]
, 1991 The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K +6 more
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Activation of Caged Functional RNAs by An Oxidative Transformation
ChemBioChem, Volume 26, Issue 8, April 14, 2025.RNAs containing 2‐thiouridine (2sUrd) in place of uridine (Urd) can exhibit loss of function. Treatment with hydrogen peroxide can convert 2sUrd to Urd. We show that a 2sUrd‐containing aptamer and ribozyme can exhibit recovery of function upon treatment with hydrogen peroxide, allowing for redox‐switched functional behavior.
Joseph M. Heili +2 more
wiley +1 more source
Genes & Development, 2016 Here, Cheng et al. present data from Tetrahymena that highlight a division of labor among ciliate piggyBac-derived genes, which carry out mutually exclusive categories of excision events mediated by either transposon-like features or RNA-directed ...
Chao-Yin Cheng +5 more
semanticscholar +1 more source
Improved Method for DNA Extraction and Purification from Tetrahymena pyriformis
Methods and Protocols, 2019 Tetrahymena pyriformis (protozoa) is intensely investigated as a model organism, offering numerous advantages in comprehensive and multidisciplinary studies using morphologic or molecular methods.
Ezzouhra El Maaiden +4 more
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PLoS ONE, 2023 Tetrahymena are ciliated protists that have been used to study the effects of toxic chemicals, including anticancer drugs. In this study, we tested the inhibitory effects of six pyrimidine analogs (5-fluorouracil, floxuridine, 5'-deoxy-5-fluorouridine, 5-
Zander Harpel +7 more
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The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids. [PDF]
, 2015 Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN)
Akiyama, Benjamin M +2 more
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Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, Volume 12, Issue 16, April 24, 2025.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
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