Results 131 to 140 of about 997 (192)

Synthesis of some novel steroidal 1,2,4,5-tetraoxanes

RSC Advances, 2015
A facile synthesis of A-ring manipulated C-20 methyl carboxylate steroid derivative with unsymmetrical dispiro 1,2,4,5-tetraoxanes has been focused herein via acid catalyzed cyclocondensation of bis-epidioxy ketone.
A. Das, Manash Hazarika
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Tetraoxanes as a new class of efficient herbicides comparable with commercial products.

Pest Management Science, 2015
BACKGROUND Several 1,2,4,5-tetraoxanes were synthesised, and their herbicidal activity was tested against weeds and compared with the activity of commercial herbicides glyphosate and imazethapyr. RESULTS The compounds were prepared by reacting carbonyl
R. C. Cusati, L. Barbosa, C. R. A. Maltha, A. Demuner, A. Oliveros-Bastidas, A. A. Silva   +5 more
semanticscholar   +4 more sources

Medicinal chemistry perspectives of trioxanes and tetraoxanes.

Current Medicinal Chemistry, 2011
Trioxane based compounds such as artemisinin and its synthetic and semi-synthetic analogues constitute promising class of antimalarial agents. The pharmaceutical development of artemisinin was started in 1971 after the isolation from Chinese medicinal ...
N. Kumar, Manik Sharma, D. Rawat
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Broadly applicable synthesis of 1,2,4,5-tetraoxanes.

Organic Letters, 2009
Re(2)O(7) is a mild and efficient catalyst for the high-yielding condensation of 1,1-dihydroperoxides with ketones or aldehydes to form 1,2,4,5-tetraoxanes, including targets not easily prepared via existing methodology.
P. Ghorai, P. Dussault
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Synthesis and Antimalarial-Activity Evaluation of TetraoxaneTriazine Hybrids and Spiro[piperidine-4,3′-tetraoxanes]

Helvetica Chimica Acta, 2012
A series of tetraoxanetriazine hybrids and spiro[piperidine-4,3′-tetraoxanes] have been synthesized, and all the compounds were screened for in vitro antimalarial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of ...
Nitin Kumar, Shabana I. Khan, D. Rawat
semanticscholar   +3 more sources

Access to Nonsymmetrical Tri- and Tetraoxanes with Silica Sulfuric Acid [PDF]

Synfacts, 2021
P. Richardson, John Lee
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An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Medicinal research reviews (Print), 2023
The demand for novel, fast‐acting, and effective antimalarial medications is increasing exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading, pose a serious threat to global health.
Monika Shukla, Komal Rathi, Mohammad Hassam, Dinesh Yadav, Manvika Karnatak, Varun Rawat, V. P. Verma   +6 more
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Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Medicinal Research Reviews, 2012
AbstractThe discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy. This discovery was the beginning of exploring peroxides as potential replacements for the traditional antimalarial drugs such as chloroquine and mefloquine.
Nitin Kumar, R. Singh, D. Rawat
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Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid.

Journal of Organic Chemistry, 2021
A novel protocol for the preparation of non-symmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes, promoted by the heterogeneous silica sulfuric acid (SSA) catalyst, is reported.
Patrícia S. M. Amado, L. Frija, Jaime A. S. Coelho, P. O’Neill, M. L. S. Cristiano   +4 more
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Chemometric methods in antimalarial drug design from 1,2,4,5-tetraoxanes analogues

SAR and QSAR in environmental research (Print), 2020
A set of 23 steroidal 1,2,4,5-tetraoxane analogues were studied using quantum-chemical method (B3LYP/6-31 G*) and multivariate analyses (PCA, HCA, KNN and SIMCA) in order to calculate the properties and correlate them with antimalarial activity (log RA ...
E. B. Costa, Raí C Silva, Raí C Silva, Raí C Silva, J. M. Espejo-Román, M. F. A. Neto, J. Cruz, Franco Henrique Andrade Leite, Carlos Henrique Tomich de Paula da Silva, Carlos Henrique Tomich de Paula da Silva, José Ciríaco Pinheiro, W. J. C. Macêdo, W. J. C. Macêdo, Cleydson B. R. Santos, Cleydson B. R. Santos   +14 more
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