Results 141 to 150 of about 997 (192)

New Preparation of 1,2,4,5‐Tetraoxanes.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Yu. N. Ogibin, Gennady I. Nikishin, M. Yu. Antipin, Alexander O. Terent'ev, Zoya A. Starikova, Alexander V. Kutkin   +5 more
openaire   +3 more sources

Tetraoxane Antimalarials and Their Reaction with Fe(II)

Journal of Medicinal Chemistry, 2006
Mixed tetraoxanes 5a and 13 synthesized from cholic acid and 4-oxocyclohexanecarboxylic acid were as active as artemisinin against chloroquine-susceptible, chloroquine-resistant, and multidrug-resistant Plasmodium falciparum strains (IC50, IC90). Most active 13 is metabolically stable in in vitro metabolism studies.
Opsenica, Igor, Terzić-Jovanović, Nataša, Opsenica, Dejan, Angelovski, Goran, Lehnig, Manfred, Eilbracht, Peter, Tinant, Bernard, Juranić, Zorica, Smith, Kirsten S., Yang, Young S., Diaz, Damaris S., Smith, Philip L., Milhous, Wilbur K., Đoković, Dejan, Šolaja, Bogdan   +14 more
openaire   +6 more sources

On the equilibrium in the system trioxane-tetraoxane-polyoxymethylene

Polymer Science U.S.S.R., 1972
Kateřina Bogdanová, G.V. Rakova, А. А. Берлин, N.S. Yenikolopyan   +3 more
openalex   +3 more sources

Growth and perfection of tetraoxane crystals

Journal of Crystal Growth, 1979
Tetraoxane (-CH2-O-)4 crystals grown by evaporation of solutions in acetone were examined by X-ray topography. Two types of crystals, long rod-shaped and thin plate-like, were obtained. No axial screw dislocation was observed. Dislocations with Burgers vectors 〈010〉 and 12〈110〉 were observed.
Tohru Watanabe, Kunihide Izumi
openalex   +3 more sources

Chemiluminescence in decomposition of bridged 1,2,4,5-tetraoxanes catalyzed by ferrocene

Mendeleev Communications, 2017
Chemiluminescence was observed in ferrocene-catalyzed decomposition of bridged 1,2,4,5-tetraoxanes, namely, 2,3,5,6-tetraoxabicyclo[2.2.1]heptanes. The chemi- and photoluminescence spectra revealed the main products and luminescence emitters to be β-diketones.
D. I. Galimov, D. R. Gazeeva, R. G. Bulgakov, A. Terent’ev   +3 more
semanticscholar   +3 more sources

Antimalarial and antiproliferative evaluation of Bis-Steroidal tetraoxanes

Bioorganic & Medicinal Chemistry, 2003
Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains.
Opsenica Dejan, Angelovski Goran, Pocsfalvi Gabriella, Juranic Zorica, Zizak Zeljko, Kyle Dennis, Milhous Wilbur K, Solaja Bogdan A   +7 more
openaire   +9 more sources

Catalyst development for the synthesis of ozonides and tetraoxanes under heterogeneous conditions. Disclosure of an unprecedented class of fungicides for agricultural application.

Chemistry, 2019
The catalyst H 3+x PMo 12-x +6 Mo x +5 O 40 supported on SiO 2 was developed for peroxidation of 1,3- and 1,5-diketones with hydrogen peroxide with the formation of bridged 1,2,4,5-tetraoxanes and bridged 1,2,4-trioxolanes (ozonides) with high yield ...
I. Yaremenko, P. Radulov, Y. Belyakova, A. A. Demina, Dmitriy I. Fomenkov, D. V. Barsukov, I. Subbotina, F. Fleury, A. Terent’ev   +8 more
semanticscholar   +1 more source

Mixed tetraoxanes containing the acetone subunit as antimalarials

Bioorganic & Medicinal Chemistry, 2008
Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-
Opsenica, Dejan, Terzić-Jovanović, Nataša, Smith, P.L., Yang, Y., Anova, L., Smith, K. S., Šolaja, Bogdan   +6 more
openaire   +5 more sources

Deoxycholic Acid-Derived Tetraoxane Antimalarials and Antiproliferatives

Journal of Medicinal Chemistry, 2007
The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors:  besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low ...
Terzić-Jovanović, Nataša, Opsenica, Dejan, Milić, Dragana, Tinant, Bernard, Smith, K. S., Milhous, Wilbur K., Šolaja, Bogdan   +6 more
openaire   +4 more sources

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Journal of Medicinal Chemistry, 2014
The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to prevent development of resistant strains of Plasmodium parasites. Our previous work demonstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles comparable to artemisinin and chloroquine while acting ...
Oliveira, Rudi, Guedes, Rita C., Meireles, Patrícia, Albuquerque, Inês S., Gonçalves, Lídia M., Pires, Elisabete, Bronze, Maria Rosário, Gut, Jiri, Rosenthal, Philip J., Prudêncio, Miguel, Moreira, Rui, O’Neill, Paul M., Lopes, Francisca   +12 more
openaire   +3 more sources