Results 141 to 150 of about 1,048 (196)

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Medicinal Research Reviews, 2012
AbstractThe discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy. This discovery was the beginning of exploring peroxides as potential replacements for the traditional antimalarial drugs such as chloroquine and mefloquine.
Nitin Kumar, R. Singh, D. Rawat
semanticscholar   +4 more sources

An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Medicinal research reviews (Print), 2023
The demand for novel, fast‐acting, and effective antimalarial medications is increasing exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading, pose a serious threat to global health.
Monika Shukla, Komal Rathi, Mohammad Hassam, Dinesh Yadav, Manvika Karnatak, Varun Rawat, V. P. Verma   +6 more
semanticscholar   +1 more source

Synthesis of some novel steroidal 1,2,4,5-tetraoxanes

RSC Advances, 2015
A facile synthesis of A-ring manipulated C-20 methyl carboxylate steroid derivative with unsymmetrical dispiro 1,2,4,5-tetraoxanes has been focused herein via acid catalyzed cyclocondensation of bis-epidioxy ketone.
A. Das, Manash Hazarika
semanticscholar   +2 more sources

Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid.

Journal of Organic Chemistry, 2021
A novel protocol for the preparation of non-symmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes, promoted by the heterogeneous silica sulfuric acid (SSA) catalyst, is reported.
Patrícia S. M. Amado, L. Frija, Jaime A. S. Coelho, P. O’Neill, M. L. S. Cristiano   +4 more
semanticscholar   +1 more source

Broadly applicable synthesis of 1,2,4,5-tetraoxanes.

Organic Letters, 2009
Re(2)O(7) is a mild and efficient catalyst for the high-yielding condensation of 1,1-dihydroperoxides with ketones or aldehydes to form 1,2,4,5-tetraoxanes, including targets not easily prepared via existing methodology. When applied in tandem with a recently reported Re(VII)-catalyzed synthesis of 1,1-dihydroperoxides, the reaction provides a high ...
P. Ghorai, P. Dussault
semanticscholar   +4 more sources

Synthesis and Antimalarial-Activity Evaluation of TetraoxaneTriazine Hybrids and Spiro[piperidine-4,3′-tetraoxanes]

Helvetica Chimica Acta, 2012
AbstractA series of tetraoxanetriazine hybrids and spiro[piperidine‐4,3′‐tetraoxanes] have been synthesized, and all the compounds were screened forin vitroantimalarial activity against chloroquine‐sensitive (D6) and chloroquine‐resistant (W2) strains ofPlasmodium falciparum.Most of the spiro[piperidine‐4,3′‐tetraoxanes] exhibited moderate to good ...
Nitin Kumar, Shabana I. Khan, D. Rawat
semanticscholar   +2 more sources

New Preparation of 1,2,4,5‐Tetraoxanes.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Yu. N. Ogibin, A. O. Terent’ev, A. V. Kutkin, Z. A. Starikova, M. Yu. Antipin, G. I. Nikishin   +5 more
openaire   +1 more source

Deoxycholic Acid-Derived Tetraoxane Antimalarials and Antiproliferatives

Journal of Medicinal Chemistry, 2007
The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors:  besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low ...
Terzić-Jovanović, Nataša, Opsenica, Dejan, Milić, Dragana, Tinant, Bernard, Smith, K. S., Milhous, Wilbur K., Šolaja, Bogdan   +6 more
openaire   +3 more sources

Catalyst development for the synthesis of ozonides and tetraoxanes under heterogeneous conditions. Disclosure of an unprecedented class of fungicides for agricultural application.

Chemistry, 2019
The catalyst H 3+x PMo 12-x +6 Mo x +5 O 40 supported on SiO 2 was developed for peroxidation of 1,3- and 1,5-diketones with hydrogen peroxide with the formation of bridged 1,2,4,5-tetraoxanes and bridged 1,2,4-trioxolanes (ozonides) with high yield ...
I. Yaremenko, P. Radulov, Y. Belyakova, A. A. Demina, Dmitriy I. Fomenkov, D. V. Barsukov, I. Subbotina, F. Fleury, A. Terent’ev   +8 more
semanticscholar   +1 more source

Tetraoxane Antimalarials and Their Reaction with Fe(II)

Journal of Medicinal Chemistry, 2006
Mixed tetraoxanes 5a and 13 synthesized from cholic acid and 4-oxocyclohexanecarboxylic acid were as active as artemisinin against chloroquine-susceptible, chloroquine-resistant, and multidrug-resistant Plasmodium falciparum strains (IC50, IC90). Most active 13 is metabolically stable in in vitro metabolism studies.
Opsenica, Igor, Terzić-Jovanović, Nataša, Opsenica, Dejan, Angelovski, Goran, Lehnig, Manfred, Eilbracht, Peter, Tinant, Bernard, Juranić, Zorica, Smith, Kirsten S., Yang, Young S., Diaz, Damaris S., Smith, Philip L., Milhous, Wilbur K., Đoković, Dejan, Šolaja, Bogdan   +14 more
openaire   +5 more sources