Results 151 to 160 of about 1,048 (196)

Antimalarial and antiproliferative evaluation of Bis-Steroidal tetraoxanes

Bioorganic & Medicinal Chemistry, 2003
Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains.
Opsenica Dejan, Angelovski Goran, Pocsfalvi Gabriella, Juranic Zorica, Zizak Zeljko, Kyle Dennis, Milhous Wilbur K, Solaja Bogdan A   +7 more
openaire   +8 more sources

Mixed Steroidal 1,2,4,5-Tetraoxanes:  Antimalarial and Antimycobacterial Activity

Journal of Medicinal Chemistry, 2002
Mixed 1,2,4,5-tetraoxanes possessing simple spirocycloalkane and spirocholic acid-derived substituents were prepared and shown to have significantly higher in vitro antimalarial activity than bis-substituted tetraoxanes. Out of 41 synthesized tetraoxanes, 12 were in vitro more potent against Plasmodium falciparum chloroquine-resistant W2 clone than ...
Solaja BA, Terzic N, Pocsfalvi G, Gerena L, Tinant B, Opsenica D, Milhous WK   +6 more
openaire   +7 more sources

Chemiluminescence in the reaction of 1,2,4,5-tetraoxanes with ferrous ions in the presence of xanthene dyes: fundamentals and perspectives of analytical applications

Photochemical and Photobiological Sciences, 2019
The reaction of biologically active bridged 1,2,4,5-tetraoxanes and diperoxide of trifluoroacetone with ferrous ions in the presence of xanthenes, methylene blue and methylene green is accompanied by bright chemiluminescence (CL) caused by the emission ...
D. V. Kazakov, T. I. Nazyrov, F. E. Safarov, I. Yaremenko, A. Terent’ev   +4 more
semanticscholar   +1 more source

Chemiluminescence in decomposition of bridged 1,2,4,5-tetraoxanes catalyzed by ferrocene

Mendeleev Communications, 2017
Chemiluminescence was observed in ferrocene-catalyzed decomposition of bridged 1,2,4,5-tetraoxanes, namely, 2,3,5,6-tetraoxabicyclo[2.2.1]heptanes. The chemi- and photoluminescence spectra revealed the main products and luminescence emitters to be β-diketones.
D. I. Galimov, D. R. Gazeeva, R. G. Bulgakov, A. Terent’ev   +3 more
semanticscholar   +2 more sources

Mixed tetraoxanes containing the acetone subunit as antimalarials

Bioorganic & Medicinal Chemistry, 2008
Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-
Opsenica, Dejan, Terzić-Jovanović, Nataša, Smith, P.L., Yang, Y., Anova, L., Smith, K. S., Šolaja, Bogdan   +6 more
openaire   +4 more sources

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Journal of Medicinal Chemistry, 2014
The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to prevent development of resistant strains of Plasmodium parasites. Our previous work demonstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles comparable to artemisinin and chloroquine while acting ...
Oliveira, Rudi, Guedes, Rita C., Meireles, Patrícia, Albuquerque, Inês S., Gonçalves, Lídia M., Pires, Elisabete, Bronze, Maria Rosário, Gut, Jiri, Rosenthal, Philip J., Prudêncio, Miguel, Moreira, Rui, O’Neill, Paul M., Lopes, Francisca   +12 more
openaire   +2 more sources

Tetraoxanes as a new class of efficient herbicides comparable with commercial products.

Pest Management Science, 2015
AbstractBACKGROUNDSeveral 1,2,4,5‐tetraoxanes were synthesised, and their herbicidal activity was tested against weeds and compared with the activity of commercial herbicides glyphosate and imazethapyr.RESULTSThe compounds were prepared by reacting carbonyl compounds with hydrogen peroxide under acid catalysis, affording 1,1‐dihydroperoxides (36–91 ...
R. C. Cusati, L. Barbosa, C. R. A. Maltha, A. Demuner, A. Oliveros-Bastidas, A. A. Silva   +5 more
semanticscholar   +3 more sources

Growth and perfection of tetraoxane crystals

Journal of Crystal Growth, 1979
Tetraoxane (-CH2-O-)4 crystals grown by evaporation of solutions in acetone were examined by X-ray topography. Two types of crystals, long rod-shaped and thin plate-like, were obtained. No axial screw dislocation was observed. Dislocations with Burgers vectors 〈010〉 and 12〈110〉 were observed.
Tohru Watanabe, Kunihide Izumi
openaire   +1 more source

Synthesis and Antimalarial Activity of 1,2,4,5‐Tetraoxanes

ChemInform, 2002
Methods for formation of 1,2,4,5-tetraoxanes are summarized and antimalarial activities of 1,2,4,5-tetraoxanes are discussed.
openaire   +2 more sources

Thermal decomposition of cyclic alkylidine peroxides (tetraoxanes)

Thermochimica Acta, 1974
Abstract Thermal decomposition of molten 6,6-bis-(4-methoxycarbonyl-butyl)-1,2,4,5-tetraoxane has kinetic parameters similar to those of the other dialkyl peroxides: A similar behaviour has also been found for 6,6-bis-(4-aminocarbonyl-butyl)-1,2,4,5-tetraoxane dissolved in dimethylformamide: In the absence of solvent this cyclic dimeric ...
M. Lazár, P. Ambrovič, E. Borsig
openaire   +1 more source