Bangladesh Journal of Pharmacology, 2015 Seven novel dispiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain
Mukesh Kumar Kumawat, Dipak Chetia
doaj +6 more sources
Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials. [PDF]
Mol Med, 2012 Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
Copple IM +13 more
europepmc +6 more sources
Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2008 Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds.
IGOR M. OPSENICA +4 more
doaj +9 more sources
AN EFFICIENT SYNTHESIS OF GEM-DIHYDROPEROXIDES AND 1,2,4,5-TETRAOXANES CATALYZED BYCHLOROSULFONIC ACIDAS A NEW CATALYST [PDF]
, 2015 Chlorosulfonic acid was used as an active, low-cost and reusable solid catalyst for conversion of ketones and aldehydes to corresponding gem-dihydroperoxides using 30% aqueous hydrogen peroxide at room temperature.
K. Khosravi, A. Asgari
semanticscholar +5 more sources
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. [PDF]
Nat Commun, 2017 Documento escrito por un elevado número de autores/as, solo se referencia el/la que aparece en primer lugar y los/as autores/as pertenecientes a la UC3M.K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium falciparum malaria ...
O'Neill PM +47 more
europepmc +6 more sources
New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum. [PDF]
Malar J, 2018 Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
Lobo L +7 more
europepmc +4 more sources
Lewis Acids and Heteropoly Acids in the Synthesis of Organic Peroxides. [PDF]
Pharmaceuticals (Basel), 2022 Organic peroxides are an important class of compounds for organic synthesis, pharmacological chemistry, materials science, and the polymer industry. Here, for the first time, we summarize the main achievements in the synthesis of organic peroxides by the
Yaremenko IA +5 more
europepmc +3 more sources
Artemisinins and synthetic peroxides as highly efficient antimalarials [PDF]
Macedonian Journal of Chemistry and Chemical Engineering, 2012 Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P. falciparum, P. ovale, P. vivax, P. malarie and P. knowlesi, from which P.
Dejan Milos Opsenica +1 more
doaj +6 more sources
Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products [PDF]
Beilstein Journal of Organic Chemistry, 2014 The present review describes the current status of synthetic five and six-membered cyclic peroxides such as 1,2-dioxolanes, 1,2,4-trioxolanes (ozonides), 1,2-dioxanes, 1,2-dioxenes, 1,2,4-trioxanes, and 1,2,4,5-tetraoxanes.
Alexander O. Terent'ev +3 more
doaj +2 more sources
Molecular and Crystal Structure, Spectroscopy, and Photochemistry of a Dispiro Compound Bearing the Tetraoxane Pharmacophore [PDF]
, 2023 The molecular structure and photochemistry of dispiro[cyclohexane-1,3′-[1,2,4,5]tetraoxane-6′,2′′-tricyclo[3.3.1.13,7]decan]-4-one (TX), an antiparasitic 1,2,4,5-tetraoxane was investigated using matrix isolation IR and EPR spectroscopies, together with ...
Patrícia S. M. Amado +7 more
openalex +4 more sources