Identification of antischistosomal leads by evaluating peroxides of beta-dicarbonyl compounds and their heteroanalogs : bridged 1,2,4,5-tetraoxanes and alphaperoxides, and beta,delta-triketones: tricyclic monoperoxides [PDF]
Journal of Medicinal Chemistry, 2012 Although antischistosomal properties of peroxides were studied in recent years, systematic structure-activity relationships have not been conducted. We evaluated the antischistosomal potential of 64 peroxides belonging to bridged 1,2,4,5-tetraoxanes ...
Hofer, L. +5 more
core +2 more sources
Elicitation effects of synthetic 1,2,4,5-tetraoxane and 2,5-diphenyltiophene in shoot cultures of two Nepeta species [PDF]
Journal of the Serbian Chemical Society, 2016 The present study was aimed to investigate the elicitation possibility of the main secondary metabolites production in Nepeta cataria L. and N. pannonica L.
Dmitrović Slavica +7 more
doaj +3 more sources
Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells [PDF]
, 2010 It was demonstrated that mixed steroidal tetraoxanes inhibit cancer cell proliferation at micromolar level through an apoptotic mechanism. It will be interesting to see if these compounds may possibly induce oxidative stress, which could lead to ...
Besu, I. +4 more
core +3 more sources
Molecular and crystal structure, spectroscopy, and photochemistry of a dispiro compound bearing the tetraoxane pharmacophore [PDF]
, 2023 The molecular structure and photochemistry of dispiro[cyclohexane-1,3′-[1,2,4,5]tetraoxane-6′,2′′-tricyclo[3.3.1.13,7]decan]-4-one (TX), an antiparasitic 1,2,4,5-tetraoxane was investigated using matrix isolation IR and EPR spectroscopies, together with ...
Abe, Manabu +7 more
core +3 more sources
Diversified Synthesis of N-Benzoyl Piperidine Tetraoxane Analogues Using Molybdenum Trioxide as a Newer Catalyst and Its Antiplasmodial Activity. [PDF]
ACS OmegaKumar A +4 more
europepmc +3 more sources
Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design. [PDF]
Drug Dev Res, 2010 Malaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of drug resistance to most of the ...
Muregi FW, Ishih A.
europepmc +3 more sources
Cover Feature: Catalyst Development for the Synthesis of Ozonides and Tetraoxanes Under Heterogeneous Conditions: Disclosure of an Unprecedented Class of Fungicides for Agricultural Application (Chem. Eur. J. 21/2020) [PDF]
, 2020 Ivan A. Yaremenko +8 more
openalex +2 more sources
Antitumor effect of steroidal tetraoxanes on malignantly transformed human cell lines [PDF]
, 2012 Uvod: Pronalaženje agenasa sa potencijalnim antitumorskim dejstvom je imperativ u modernoj onkologiji. Pri tome se sve više zapaža da određene hemijske strukture imaju specifičnije toksično dejstvo na maligne ćelije.
Žižak, Željko S.
core +4 more sources
Assessment of the antimalarial potential of tetraoxane WR 148999. [PDF]
The American journal of tropical medicine and hygiene, 2000 The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between artemisinin and chloroquine, these drug combination data imply that WR 148999 and artemisinin may not share
Jonathan L. Vennerstrom +7 more
openalex +4 more sources
Efforts Made to Eliminate Drug-Resistant Malaria and Its Challenges. [PDF]
Biomed Res Int, 2021 Since 2000, a good deal of progress has been made in malaria control. However, there is still an unacceptably high burden of the disease and numerous challenges limiting advancement towards its elimination and ultimate eradication. Among the challenges is the antimalarial drug resistance, which has been documented for almost all antimalarial drugs in ...
Amelo W, Makonnen E.
europepmc +2 more sources