Elicitation effects of synthetic 1,2,4,5-tetraoxane and 2,5-diphenyltiophene in shoot cultures of two Nepeta species [PDF]
Journal of the Serbian Chemical Society, 2016 The present study was aimed to investigate the elicitation possibility of the main secondary metabolites production in Nepeta cataria L. and N. pannonica L.
Dmitrović Slavica +7 more
doaj +3 more sources
512 Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells [PDF]
, 2010 It was demonstrated that mixed steroidal tetraoxanes inhibit cancer cell proliferation at micromolar level through an apoptotic mechanism. It will be interesting to see if these compounds may possibly induce oxidative stress, which could lead to ...
Željko Žižak +4 more
openalex +4 more sources
Cover Feature: Catalyst Development for the Synthesis of Ozonides and Tetraoxanes Under Heterogeneous Conditions: Disclosure of an Unprecedented Class of Fungicides for Agricultural Application (Chem. Eur. J. 21/2020) [PDF]
, 2020 I. Yaremenko +8 more
semanticscholar +2 more sources
Unlocking the antimalarial potential of novel steroid-tetraoxane hybrids through consensus molecular docking and molecular dynamics investigation. [PDF]
Sci RepNath D +4 more
europepmc +3 more sources
Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design. [PDF]
Drug Dev Res, 2010 Malaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of drug resistance to most of the ...
Muregi FW, Ishih A.
europepmc +3 more sources
5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents. [PDF]
Molecules, 2021 Jansongsaeng S +4 more
europepmc +3 more sources
Efforts Made to Eliminate Drug-Resistant Malaria and Its Challenges. [PDF]
Biomed Res Int, 2021 Since 2000, a good deal of progress has been made in malaria control. However, there is still an unacceptably high burden of the disease and numerous challenges limiting advancement towards its elimination and ultimate eradication. Among the challenges is the antimalarial drug resistance, which has been documented for almost all antimalarial drugs in ...
Amelo W, Makonnen E.
europepmc +2 more sources
Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane [PDF]
Journal of the Serbian Chemical Society, 2002 An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7?,12?-diacetoxy-5?-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 ?g/mL; IC50 (W2) = 0.29 ?g/mL).
Dejan Opsenica +3 more
openalex +7 more sources
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery. [PDF]
ChemMedChem, 2022 Activity‐based protein profiling has impacted several biological research areas by providing functional fingerprints of enzymatic activity in complex proteomes. We discuss the main achievements of ABPP in the field of malaria research, including characterization of pathologically‐relevant enzymes, target and mechanism deconvolution of antimalarials ...
Carvalho LAR, Bernardes GJL.
europepmc +2 more sources