Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). [PDF]
Antimicrob Agents Chemother, 2007 Dong Y +7 more
europepmc +3 more sources
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery. [PDF]
ChemMedChem, 2022 Activity‐based protein profiling has impacted several biological research areas by providing functional fingerprints of enzymatic activity in complex proteomes. We discuss the main achievements of ABPP in the field of malaria research, including characterization of pathologically‐relevant enzymes, target and mechanism deconvolution of antimalarials ...
Carvalho LAR, Bernardes GJL.
europepmc +2 more sources
Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters [PDF]
Journal of Pharmaceutical and Biomedical Analysis, 2014 Sandra Šegan +5 more
openalex +2 more sources
Elucidation of the in vitro and in vivo activities of bridged 1,2,4-trioxolanes, bridged 1,2,4,5-tetraoxanes, tricyclic monoperoxides, silyl peroxides, and hydroxylamine derivatives against Schistosoma mansoni [PDF]
Bioorganic & Medicinal Chemistry, 2015 Noemi Cowan +4 more
openalex +2 more sources
3D-QSAR Studies of Tetraoxanes Derivatives as Antimalarial Agents Using CoMFA and CoMSIA Approaches
, 2013 Tetraoxanes (1,2,4,5-tetraoxanes) have been reported to exhibit potent antimalarial activity. In the present study, the three dimensional-quantitative structure activity relationship (3D-QSAR) studies were performed on a series of tetraoxanes derivatives
Taigang Liang, Luhui Ren, Qingshan Li
openalex +3 more sources
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. [PDF]
Angew Chem Int Ed Engl, 2016 „Klickbare” 1,2,4‐Trioxolan‐Proteinprofilingsonden (ABPPs) wurden so entworfen, dass sie ihre Aktivität gegen Malaria behalten und die molekularen Targets des Blutstadiums von Plasmodium falciparum in situ alkylieren. Ein Vergleich ihrer Proteinalkylierungssignatur mit den entsprechenden Artemisinin‐ABPPs zeigt, dass beide Wirkstoffklassen ...
Ismail HM +6 more
europepmc +4 more sources
7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity [PDF]
Journal of the Serbian Chemical Society, 2004 Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains,
Opsenica Igor +4 more
doaj +3 more sources
Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis(Quaternary Ammonium Salts) [PDF]
Bioscience, Biotechnology, and Biochemistry, 2009 Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2-propanol.
Naokazu Kumura +8 more
openalex +4 more sources
Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane [PDF]
Journal of the Serbian Chemical Society, 2002 An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7?,12?-diacetoxy-5?-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 ?g/mL; IC50 (W2) = 0.29 ?g/mL).
Dejan Opsenica +3 more
openalex +7 more sources
Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2008 Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds.
IGOR M. OPSENICA +4 more
doaj +3 more sources