Pharmacological and pharmacokinetic studies on trematocidal drugs : praziquantel and two synthetic peroxide lead candidates [PDF]
, 2015 Trematodiases affect more than 250 million people worldwide, while the economic impact through veterinary infections is also colossal. Treatment options are however limited to two main drugs, triclabendazole for the liver fluke Fasciola hepatica, and ...
Meister, Isabel
core +1 more source
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
ChemMedChem, Volume 20, Issue 11, June 2, 2025.Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert +6 more
wiley +1 more source
Structure, Properties, and Biomedical Activity of Natural Sweeteners Steviosides: An Update
Food Science &Nutrition, Volume 13, Issue 2, February 2025.Stevioside is a natural sweetener with the characteristics of low calorie and high sweetness. It consists of a wide variety of monomers involved in several biological processes. It has been widely used in the food and pharmaceutical industries. As a substitute for sugar, stevioside also shows good pharmacological activities.
Aoyi Wang +7 more
wiley +1 more source
Blending lignin-derived oxygenate in enhanced multi-component diesel fuel for improved emissions [PDF]
, 2014 Experiments were conducted on a single-cylinder diesel engine to ascertain prospective improvements in engine performance and exhaust emissions with various blends of additised and non-additised diesel fuels.
A. Jones +29 more
core +2 more sources
A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy
Advanced NanoBiomed Research, Volume 4, Issue 2, February 2024.In this review, the latest progression of essential metal‐ion‐based nanomedicine for tumor therapy is summarized, existing challenges are addressed, and possible directions of such therapeutic strategies are proposed. Such information benefits readers a general awareness for current research status and implication of the future clinical applications ...
Lin Weng, Xin Chen
wiley +1 more source
Advances in the synthesis of acyclic peroxides [PDF]
, 2017 Peroxide-containing compounds are an attractive synthetic target, given their widespread abundance in nature, with many displaying potent antimalarial and antimicrobial properties.
Gandhi, Hirenkumar +5 more
core +2 more sources
Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials [PDF]
, 2014 Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
Bringela, A. +12 more
core
CRIMALDDI: a prioritized research agenda to expedite the discovery of new anti-malarial drugs [PDF]
, 2013 The CRIMALDDI Consortium has been a three-year project funded by the EU Framework Seven Programme. It aimed to develop a prioritized set of recommendations to speed up anti-malarial drug discovery research and contribute to the setting of the global ...
Boulton, Ian C, Ward, Stephen
core +4 more sources
Kinetic of the thermal decomposition of disubstituted tetroxanes [PDF]
, 2016 The thermal decomposition of diphenyl diperoxide (DFT) and dibutanal diperoxide (DPG) were investigated over the temperature range 130 to 166°C. They were found to be first order with a high degree of conversion (60%).
Bordón, Alexander Germán +6 more
core
O peroksidnim antimalaricima [PDF]
, 2007 Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials.
Jadranin, Milka +6 more
core +2 more sources