Dispiro- 1,2,4,5-tetraoxanes: A New Class of Antimalarial Peroxides [PDF]
, 1992 Dispiro-l,2,4,5tetraoxanes2 -4 were synthesized as potential peroxide a n t h a l a* d drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data Moreover, artemisinin
Ager, Arba L., Jr. +7 more
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Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes: Correlations of Structural Studies with Antimalarial Activity [PDF]
, 2000 Two tetramethyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15,16-tetraoxadispiro[5.2.5.2]- hexadecanes) 3 and 4 were designed as metabolically stable analogues of the dimethylsubstituted dispiro-1,2,4,5-tetraoxane prototype WR 148999 (2).
Dong, Yuxiang +6 more
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Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials
Tetrahedron, 2016 Abstract An efficient route to the synthesis of potent antimalarial aryloxy 1,2,4,5-tetraoxanes is described that permits parallel synthesis for Structure–Activity Relationship (SAR) investigations. Brief details of the in vitro and in vivo antimalarial evaluation are included which enables identification of antimalarial leads for further development.
Natalie L. Roberts +11 more
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Nanoencapsulation of new compounds with potentioal anti-leishmanial activity [PDF]
, 2016 Tese de mestrado, Química Farmacêutica e Terapêutica, Universidade de Lisboa, Faculdade de Farmácia, 2016Infectious diseases caused by viruses, parasites and bacteria are currently the second cause of mortality worldwide.
Quintas, João Pedro Vitorino
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An in vitro investigation into the anti-cancer potential of novel tetraoxane compounds for the treatment of chronic lymphocytic leukaemia / [PDF]
, 2018 This study aims to evaluate the therapeutic potential of five novel tetraoxane compounds and one novel tetraoxane-naphthalimide hybrid compound for chronic lymphocytic leukaemia.
O'Reilly, Alma
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs [PDF]
, 2017 The prevention and cure of malaria is difficult as it thrives under poor socio- and pharmacoeconomic conditions in third world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito.
Jihan, Mohamed Elsideiq
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Research on anthelmintic drugs, with an emphasis on structure-activity relationship and pharmacokinetic studies [PDF]
, 2015 More than one third of the world’s population is infected with at least one helminth, among which schistosomiasis and trichuriasis are highly prevalent. The control of schistosomiasis relies heavily on the treatment of people living in endemic areas with
Cowan, Noemi
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Calorimetric and Computational Study of Enthalpy of Formation of Acetone Diperoxide [PDF]
, 2012 A rather simple thermochemical experimental technique was applied to determine the enthalpy of formation of Diperoxide of acetone. The study is complemented with theoretical calculations ab initio and by the density functional theory (DFT) procedure.Una ...
Castro, Eduardo Alberto +5 more
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In silico modeling of tetraoxane-8-aminoquinoline hybrids active against Plasmodium falciparum [PDF]
, 2020 Aliyu Wappah Mahmud +2 more
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Supplementary data for article: Šegan, S. B.; Andrić, F.; Radoičić, A.; Opsenica, D. M.; Šolaja, B. A.; Zlatović, M.; Milojković-Opsenica, D. Correlation between Structure, Retention and Activity of Cholic Acid Derived Cis-Trans Isomeric Bis-Steroidal Tetraoxanes. Journal of Separation Science 2011, 34 (19), 2659–2667. https://doi.org/10.1002/jssc.201100185 [PDF]
, 2011 Supporting information for: [https://doi.org/10.1002/jssc.201100185]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789 ...
Andrić, Filip +6 more
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