Results 71 to 80 of about 9,531 (204)

The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy [PDF]

, 2014
It is well known that the activation of Aurora A/B (Aur A/B) or inactivation of BRCA1/2 induces tumor formation. Others and we have reported that the mutual suppression between Aur A/B and BRCA1/2 may manipulate cancer cell growth and tumorigenesis ...
Gong Yang, Jiao Meng, Mingming Liu, Na Zhang, Rongyu Zang, Sheng Yin, Yan Wang, Yang Liu, Zhen Zhang, Zihao Qi, Ziliang Wang   +10 more
core   +2 more sources

Tetraploidy and CIN: a dangerous combination [PDF]

Cell Cycle, 2015
Chromosomal instability (CIN) is a hallmark of cancer, and is associated with both poor prognosis and drug resistance.1 Tetraploidy has also been frequently observed in human cancer despite being a...
Sally, Dewhurst, Charles, Swanton
openaire   +2 more sources

Colchicine-Induced Polyploidy in Rhododendron fortunei Lindl

Plants, 2020
Polyploidy in Rhododendron fortunei has great potential to improve its horticultural and commercial value, and to also meet market demands. In this study, a feasible method for polyploid induction in R.
Lan Mo, Junhao Chen, Xiongzhen Lou, Qiangwei Xu, Renhui Dong, Zaikang Tong, Huahong Huang, Erpei Lin   +7 more
doaj   +1 more source

The Medicago genome provides insight into the evolution of rhizobial symbioses [PDF]

Legumes (Fabaceae or Leguminosae) are unique among cultivated plants for their ability to carry out endosymbiotic nitrogen fixation with rhizobial bacteria, a process that takes place in a specialized structure known as the nodule.
Bisseling, T., Franken, C., Geurts, R., Hartog, M.V., Lang, C., Mitani, S.   +5 more
core   +2 more sources

Degenerate Tetraploidy Was Established Before Bdelloid Rotifer Families Diverged [PDF]

, 2008
Rotifers of Class Bdelloidea are abundant freshwater invertebrates known for their remarkable ability to survive desiccation and their lack of males and meiosis.
Hur, Jae H., Mandigo, Morgan L., Meselson, Matthew, Van Doninck, Karine   +3 more
core   +2 more sources

Cyclin D mediates tolerance of genome-doubling in cancers with functional p53 [PDF]

, 2017
BACKGROUND: Aneuploidy and chromosomal instability (CIN) are common features of human malignancy that fuel genetic heterogeneity. Although tolerance to tetraploidization, an intermediate state that further exacerbates CIN, is frequently mediated by TP53 ...
Begum, J, Cerveira, J, Crockford, A, Cuomo, ME, Dewhurst, SM, Encheva, V, Grönroos, E, McGranahan, N, Patel, H, Purewal, S, Renshaw, MJ, Snijders, AP, Swanton, C, Zalmas, LP   +13 more
core  

Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation

International Journal of Gynecology &Obstetrics, Volume 172, Issue 1, Page 25-50, January 2026.
Abstract Mid‐trimester pregnancy loss (MTL), defined as a pregnancy loss occurring between 14 + 0 and 21 + 6 weeks of gestation, causes significant physical and emotional distress to women and presents clinical challenges to healthcare professionals. It is acknowledged that in low‐resource settings, this guideline might be applicable to births up to 28 
Caroline E. Fox, Rosinder Kaur, Kugajeevan Vigneswaran, Rachel Small, Jenny Carter, Keelin O'Donoghue, Alexander E. P. Heazell, Anna L. David, Nigel Simpson, Angharad Care, Lisa Starrs, Andrew Shennan, Catalina María Valencia González, Priya Soma‐Pillay, Leah Fitzsimmons, Adam J. Devall, Arri Coomarasamy, Mid‐trimester Pregnancy Loss Guideline Consensus Panel, Owen Arthurs, Ruth Bender‐Atik, Phil Bennett, Kirstien Boelaert, Elizabeth Bonney, Leanna Brace, Naomi Carlisle, Davide Casagrandi, Manju Chandiramani, Carolyn Chiswick, Alexandra Emms, Stella Fielder, James Goadsby, Laura Goodfellow, Jim Gray, Jemma Johns, Emma Kirk, Will Lester, Sophie Mackay, Maria Memtsa, Katie Morris, Sunbal Mukhtar, Naimah Raza, Rita Sarquis, Neil Sebire, Lucy Smith, Lucy Spencer, Amos Tetteh, Natalie Woodhead   +46 more
wiley   +1 more source

Identification of chromosomal abnormalities and genomic features in near-triploidy/tetraploidy-acute leukemia by fluorescence in situ hybridization

Cancer Management and Research, 2019
Ruqing Yang,1 Minghua Jiang,2 Junzhao Zhao,1 Hui Chen,2 Jian Gong,2 Yaying You,3 Laiyue Song,3 Zhen Li,4 Qian Li2 1Reproductive Medicine Center, Department of Gynaecology and Obstetrics, The Second Affiliated Hospital and Yuying Children’s Hospital
Yang R, Jiang M, Zhao J, Chen H, Gong J, You Y, Song L, Li Z, Li Q   +8 more
doaj  

DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. [PDF]

PLoS ONE, 2010
During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis.
Yosuke Ichijima, Ken-ichi Yoshioka, Yoshiko Yoshioka, Keitaro Shinohe, Hiroaki Fujimori, Junya Unno, Masatoshi Takagi, Hidemasa Goto, Masaki Inagaki, Shuki Mizutani, Hirobumi Teraoka   +10 more
doaj   +1 more source

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, Volume 7, Issue 1, January 2026.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source