Results 31 to 40 of about 1,810 (150)

Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target

Journal of Cellular and Molecular Medicine, Volume 26, Issue 9, Page 2557-2565, May 2022., 2022
Abstract Although small‐cell lung cancer (SCLC) accounts for a small fraction of lung cancer cases (~15%), the prognosis of patients with SCLC is poor with an average overall survival period of a few months without treatment. Current treatments include standard chemotherapy, which has minimal efficacy and a newly developed immunotherapy that thus far ...
Jungang Chen, Lindsey Barrett, Zhen Lin, Samantha Kendrick, Shengyu Mu, Lu Dai, Zhiqiang Qin   +6 more
wiley   +1 more source

VIABILIDADE DE SEMENTES DE CASTANHA-DO-BRASIL PELO TESTE DE TETRAZÓLIO

, 2020
Objetivou-se revisar e propor o protocolo de viabilidade das sementes da Bertholletia excelsa pelo teste de tetrazolio. Sementes oriundas de plantio comercial propagado por enxertia com 16 anos de idade implantadas na Fazenda Iracema em Claudia, MT ...
D. R. Borella, Andréa Carvalho Da Silva, Júlio Henrique Germano de Souza, C. Martim, Mariana Pizzatto, Kalisto Natam Carneiro Silva   +5 more
semanticscholar   +1 more source

Imagens digitalizadas na avaliação do teste de tetrazólio em sementes de trigo

Colloquium Agrariae, 2020
The tetrazolium test can be an alternative to obtain fast results of the physiological potential of wheat seeds. In this context, the objective of the present study was to evaluate the efficiency of the tetrazolium test through the evaluation by analysis
Emanueli Bastos Garcia, M. R. Ávila, N. Junior, G. T. Nagashima   +3 more
semanticscholar   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, Volume 36, Issue 38, 11 May 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based local
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Mesoporous Silica Nanoparticles‐Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin

Small, Volume 22, Issue 24, 27 April 2026.
This work explores the tailored functionalization of mesoporous silica nanoparticles (MSN) to improve the oral delivery of insulin, as a case study. Insulin confinement within silica mesopores increased drug solubility, and co‐formulation with succinylated β‐lactoglobulin yielded pH‐responsive tablets that limited gastric release and proteolysis, while
Claudia Iriarte‐Mesa, Estelle Juère, Andrea Bileck, Thomas Kremsmayr, Michael L. Goodson, Allison Ehrlich, Adnan Hodžić, Martin Kunert, Christopher Gerner, Hanspeter Kählig, Doris Marko, Markus Muttenthaler, David Berry, Giorgia Del Favero, Freddy Kleitz   +14 more
wiley   +1 more source

Polymethoxylated N‐Carboranyl Isoquinolinones: A New Scaffold for ABCG2 Inhibitors

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
Combinations of a boron‐based clusters (carborane) and polymethoxy group patterns are crucial to overcome ABCG2‐mediated multidrug resistance in cancer cells. (Created in BioRender. Kuhnert, L. (2025) https://BioRender.com/h4cnh5m). ABCG2‐mediated multidrug resistance (MDR) is a major challenge among chemotherapeutic treatments of colon, pancreatic ...
Lydia Kuhnert, Philipp Stockmann, Peter Lönnecke, Mara Anna Wolniewicz, Evamarie Hey‐Hawkins, Walther Honscha   +5 more
wiley   +1 more source

Determinación del vigor por tetrazolio en semillas de maní (Arachis hypogaea L.) bajo distintas condiciones de almacenamiento

AgriScientia, 1997
Para el análisis de vigor por tetrazolio en semillas de maní aún no se dispone de patrones de evaluación adecuados. El objetivo de este trabajo fue elaborar un patrón de tinción para la determinación del vigor en semillas de maní, sometidas a diferentes condiciones de almacenamiento en relación con la emergencia de plántulas a campo.
M. A. Pérez, J. A. Argüello
openaire   +1 more source

Ultrathin Self‐Assembled and Surface‐Attached Hydrogel Coating on Titanium for Potential Nanogluing of Implants

Journal of Applied Polymer Science, Volume 142, Issue 33, September 5, 2025.
A self‐assembling and surface‐attached hydrogel coating was developed for titanium, combining phosphonate anchoring and phenyl azide crosslinking. The ultrathin, swellable films show long‐term stability, biocompatibility, and strong nanoparticle immobilization.
Laura Finck, Valentin Hagemann, Jana Schwieger, Verena Scheper, Nina Ehlert, Sebastian Polarz, Henning Menzel   +6 more
wiley   +1 more source

Histoquímica de la reacción Hidroquinona-tetrazolio-reductasa en el sistema nervioso central del ratón en desarrollo

Revista de Medicina de la Universidad de Navarra, 2017
Se ha realizado un estudio histoquímico de la reacción Hidroquinona tetrazolio-reductasa en cortes seriados de criostato, correspondientes al sistema nervioso central de ratones de distintas edades a partir del nacimiento. Previa fijación de unos modelos citoquímicos-neuropílicos, se estudian evolutivamente las intensidades de las ...
J. R. Iglesias, F. Hernández
openaire   +1 more source

Preparo da semente de colubrina para execução do teste de tetrazólio

Revista Verde de Agroecologia e Desenvolvimento Sustentável, 2019
Colubrina glandulosa Perkins, conhecida popularmente como sobrasil, é uma espécie de importância ecológica e socioeconômica, porém ameaçada de extinção. Suas sementes apresentam germinação baixa, lenta e desuniforme. Sabendo que o teste de tetrazólio tem
Pablo Henrique Fernandes Moraes, Laura Veríssimo Cavalcante, Asclépio Silva de Albuquerque, Amanda Maria Carlos Rodrigues, Luan Danilo Ferreira de Andrade Melo, João Luciano de Andrade Melo Júnior   +5 more
semanticscholar   +1 more source