Results 121 to 130 of about 675,988 (246)

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

open access: yesDrug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu   +7 more
wiley   +1 more source

Treatment with Plasma Activated (Salt) Water Sterilizes Macromolecular Coatings While Maintaining Their Integrity and Functionality

open access: yesAdvanced Materials Interfaces, Volume 13, Issue 3, 3 February 2026.
PDMS samples were covalently coated with mucin glycoproteins and then treated with either plasma activated water (PAW) or saline (PAS) as a means of disinfection. The samples could be successfully sterilized without compromising the structural integrity or functionality of those coatings.
Bernardo Miller Naranjo   +4 more
wiley   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

open access: yesChemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy   +4 more
wiley   +1 more source

Identification of Antioxidant, Antimicrobial, and Cytotoxic Compounds From Hymenocardia acida Tul. Using Ultra‐High‐Performance Liquid Chromatography‐Quadrupole Exactive‐Orbitrap‐Mass Spectrometry and Molecular Networking Approach

open access: yesChemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT Hymenocardia acida Tul. is a medicinal plant used in Angola to treat microbial diseases. It is a well‐known plant among local populations; however, few studies have focused on the assessment of phytochemicals associated with their biological activities.
Ntsoaki Joyce Malebo   +4 more
wiley   +1 more source

Integrated green extraction of phenolic compounds and fermentable sugars from grapefruit peel using ultrasound and enzymatic hydrolysis

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 3, Page 1839-1851, February 2026.
Abstract BACKGROUND Valorizing sugar‐rich food waste in biorefineries offers a sustainable route to bio‐based products. Grapefruit peel (GP), representing about 50% of the fruit's weight, is rich in sugars (soluble and insoluble) and polyphenols such as flavonoids.
María del Prado García‐Aparicio   +2 more
wiley   +1 more source

Trichostatin A Sensitizes Tumor Cells to Apoptosis Induced by Soluble Trimeric TRAIL‐Expressing Human Mesenchymal Stromal Cells

open access: yesCancer Science, Volume 117, Issue 2, Page 456-467, February 2026.
Human mesenchymal stromal cells (MSCs) were engineered to secrete an isoleucine‐zippered soluble trimeric TRAIL (SCZT) and evaluated with trichostatin A (TSA) to overcome TRAIL resistance. TSA upregulated DR5 and amplified caspase‐8–dependent apoptosis in vitro; in vivo, tumor‐homing MSCs combined with TSA suppressed the growth of both TRAIL‐sensitive ...
Ryosuke Uchibori   +2 more
wiley   +1 more source

Cytotoxicity of ammonia‐ and water‐based silver fluoride treatments

open access: yesEuropean Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract This study aims to investigate the trans‐dentinal and direct cell viability of ammonia‐ and water‐based silver fluoride treatments. Deep dentin discs were prepared, balanced for permeability and autoclaved. Three‐dimensional cultures of odontoblast‐like cells were transferred to the pulpal aspect of the dentin slices inside perfusion split ...
Merve Uctasli   +3 more
wiley   +1 more source

Interactions of 2,3,5-triphenyl-2-tetrazolium chloride with poly(sodium 4-styrenesulfonate) studied by diafiltration and UV?vis spectroscopy

open access: green, 2004
Ignacio Moreno‐Villoslada   +5 more
openalex   +2 more sources

The CCL11‐CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Schematic diagram of the triggering mechanism of necroptosis after cerebral ischemia. First, CCL11 targetedly binds to CCR3 on the surface of astrocytes and upregulates the expression of CCR3. After CCR3 activation, it triggers the transcriptional activation of necroptosis.
Han Yin   +10 more
wiley   +1 more source

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