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Tetrazolium Salts and Formazans
Progress in Histochemistry and Cytochemistry, 1976The history of the tetrazolium salts and formazans goes back 100 years, to when Friese (1875) reacted benzene diazonium nitrate with nitromethane, to produce a cherry-red "Neue Verbindung". This was the first formazan. 19 years later, Von Pechmann and Runge (1894) oxidised a formazan to produce the first tetrazolium salt.
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Microculture tetrazolium assays: a comparison between two new tetrazolium salts, XTT and MTS
Journal of Immunological Methods, 1995Microculture tetrazolium assays are being widely exploited to investigate the mechanisms of both cell activation and cell damage. They are colorimetric assays which are based upon the bioreduction of a tetrazolium salt to an intensely coloured formazan.
C J, Goodwin +3 more
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