Results 41 to 50 of about 750,402 (305)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2019 Purpose: Despite its availability for more than a decade, the human papillomavirus (HPV) vaccine has low uptake in Texas (49%). The objective of this study was to understand parental knowledge and attitudes about HPV and the HPV vaccine as well as child ...
Melissa Victory +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Nuisance American alligators: an investigation into trends and public opinion
Human-Wildlife Interactions, 2017 The population rebound of the American alligator (Alligator mississippiensis; hereafter, alligator), with the rapid growth of populations throughout its range, has caused an influx of human–alligator conflicts.
Cord B. Eversol +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
AIA Avances en Investigación Agropecuaria, 2017 El orégano es una especie de amplia distribución en territorio mexicano, donde sus poblaciones se han adaptado a condiciones geoclimáticas muy diversas.
Jesús Di Carlo Quiroz Velásquez +4 more
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Demographic and Spatial Characteristics of Feral Hogs in the Chihuahuan Desert, Texas
Human-Wildlife Interactions, 2017 Feral hogs (Sus scrofa) have recently expanded their range to include portions of the arid regions of the Chihuahuan Desert, Texas. We examined feral hog density, survival rates, range size, and habitat use in the Davis Mountains, Texas, to understand ...
Roger N. Adkins, Louis A. Harveson
doaj +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Integración regional binacional: Evidencia para los estados del norte de México y Texas
Frontera Norte, 2009 El presente estudio busca contribuir al análisis de la integración regional entre los estados del norte de la república y el estado de Texas, mediante el uso de modelos de series de tiempo.
Edgardo Arturo Ayala Gaytán +2 more
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