Results 61 to 70 of about 661,400 (268)

Integración regional binacional: Evidencia para los estados del norte de México y Texas

Frontera Norte, 2009
El presente estudio busca contribuir al análisis de la integración regional entre los estados del norte de la república y el estado de Texas, mediante el uso de modelos de series de tiempo.
Edgardo Arturo Ayala Gaytán, Joana Cecilia Chapa Cantú, Izabel Diana Hernández González   +2 more
doaj  

Green Turtle (Chelonia mydas) Nesting Underscores the Importance of Protected Areas in the Northwestern Gulf of Mexico

Frontiers in Marine Science, 2020
Knowledge of the spatial and temporal distribution of green sea turtle (Chelonia mydas) nesting is crucial for management of this species. Limited data exist on the nesting patterns of green turtles along the northwestern Gulf of Mexico (GoM) coast. From
Donna J. Shaver, Hilary R. Frandsen, Jeffrey A. George, Christian Gredzens   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Laurus macrocarpa Lesquereux from the mid-Cretaceous (Cenomanian) Dakota Formation, USA, is a chlamydospermous seed, not an angiosperm fruit

Acta Palaeobotanica
The fossil seed, Decaturospermum macrocarpum (Lesquereux) gen. nov. et comb. nov., is described based on specimens of latest Albian to mid-Cenomanian age (mid-Cretaceous) from the Dakota Formation of Nebraska, and Kansas, USA, which were previously ...
Steven R. Manchester, Peter R. Crane
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Mazanet's 1693 "Report to the Viceroy:" The Role of Alterity, Bare Life, and Agency in the Attitude of a Spanish Friar against Texas Amerindians

The Coastal Review, 2018
This study evaluates Spanish missionary Damián Mazanet’s beliefs and attitudes about the Texas Indians expressed in a 1693 letter. In order to control the Amerindians, Mazanet represents them as beings with bare life, which gives him permission to ...
Pedro Cebollero
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source