Results 41 to 50 of about 3,251,756 (318)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The emergence of a texas collaboration to improve well-being in learning health systems
Medical Education Online, 2021 Prior models of well-being have focused on resolving issues at different levels within a single institution. Changes over time in medicine have resulted in massive turnover and reduced clinical hours that portray a deficit-oriented system.
Toi B. Harris +4 more
doaj +1 more source
Texas Rail System Plan Summary [PDF]
, 2005 Summary of current and proposed rail projects including infrastructure and capacity needs on the Texas rail ...
Texas. Department of Transportation.
core
Texas Adopted Textbook List 2012
, 2012 List of textbooks adopted by the State of Texas for use in K-12 public schools.UT ...
Texas State Department of Education
core +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Education Policy Analysis Archives, 2019 In Texas, local taxpayers fund the majority of educational facilities construction and maintenance costs, with local wealth influencing facilities outcomes.
Marialena D. Rivera, Sonia Rey Lopez
doaj +1 more source
, 1940 Map of Miami, Roberts County, Texas. Map of Roberts County, Texas, showing water wells and springs. Work projects administration project 13673. Analyses made and report mimeographed by Work Projects Administration, project 10443.
Texas Board of Water Engineers
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source