Results 71 to 80 of about 22,526,023 (342)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Microscopic description of $^7$Li in the $^{7}\text{Li}+^{12}\text{C}$ and $^7\text{Li}+^{28}\text{Si}$ elastic scattering at high energies

, 2014
We employ a microscopic continuum-discretized coupled-channels reaction framework (MCDCC) to study the elastic angular distribution of the $^7$Li$=\alpha+t$ nucleus colliding with $^{12}$C and $^{28}$Si targets at $E_{\text{Lab}}$=350 MeV.
Descouvemont, P., Pinilla, E. C.
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Dataset for Siswati: Parallel textual data for English and Siswati and monolingual textual data for Siswati

Data in Brief
This data article presents a dataset for Siswati, a Bantu language of the Nguni group that is one of the eleven official South African languages and the official language of Eswatini (together with English).
Tanja Gaustad, Cindy A. McKellar, Martin J. Puttkammer   +2 more
doaj   +1 more source

Features of the perception and understanding of emoji by adolescents with different levels of intelligence

Mediterranean Journal of Clinical Psychology, 2020
The present study aims at the comparative analysis of the patterns of the identification of images that reflect basic and complex emotions by adolescents with mild intellectual disturbances and by normatively developing peers.
Oksana Zashchirinskaia, Elena Nikolaeva, Hagedorn Udo   +2 more
doaj   +1 more source

Ambitions and Text [PDF]

, 2005
Reviews the book Well Dreams: Essays on John Montague, edited by Thomas Dillon ...
Farrell, Tyler
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Viability of Neural Networks for Core Technologies for Resource-Scarce Languages

Information, 2020
In this paper, the viability of neural network implementations of core technologies (the focus of this paper is on text technologies) for 10 resource-scarce South African languages is evaluated.
Melinda Loubser, Martin J. Puttkammer
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source