Results 31 to 40 of about 2,419,982 (257)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

En apologi för nyttan

Kulturella Perspektiv, 2008
"An apology for usefulness" is discussing the crisis of Comparative Literature in Sweden in terms of tradition and usefulness. The origin of literary history both as genre and discipline is connected to the nineteenth century's nationalism and the ...
Lisbeth Larsson
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Structure and access : the role of structural factors in text comprehension and information [PDF]

, 1985
In this thesis it is argued that structural factors play an important role in facilitating the access, comprehension, and recall of textual information, especially when the content of the material is unfamiliar to the reader.
O'Malley, C.E, O'Malley, Claire E.
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Quantitative text analysis

Nature Reviews Methods Primers
Text analysis has undergone substantial evolution since its inception, moving from manual qualitative assessments to sophisticated quantitative and computational methods. Beginning in the late twentieth century, a surge in the utilization of computational techniques reshaped the landscape of text analysis, catalysed by advances in computational power ...
Kristoffer L. Nielbo, Folgert Karsdorp, Melvin Wevers, Alie Lassche, Rebekah B. Baglini, Mike Kestemont, Nina Tahmasebi   +6 more
openaire   +6 more sources

Text analysis in financial disclosures

CoRR, 2020
Financial disclosure analysis and Knowledge extraction is an important financial analysis problem. Prevailing methods depend predominantly on quantitative ratios and techniques, which suffer from limitations like window dressing and past focus. Most of the information in a firm's financial disclosures is in unstructured text and contains valuable ...
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Bi-Stretched Exponential Model and Parameters Estimation Based on Dual Minimization Deep Neural Network

Journal of Harbin University of Science and Technology
Intravoxel incoherent motion ( IVIM) is the only medical imaging technique that does not require contrast agent. However, existing bi-exponential model cannot reflect the non-Gaussian features of diffusion and perfusion motions, and the fitting method of
LEI Chao, YE Chen, WANG Lihui
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source