Results 51 to 60 of about 2,419,982 (257)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Assessing critical thinking disposition through text analysis in traditional Chinese: An empirical study of tourism and gaming undergraduates in Macao

Frontiers in Education
Critical thinking disposition (CTD) is increasingly recognized as an important trait in education, reflecting the inclination and habits necessary for addressing complex challenges in today's world.
Carlos Siu Lam, Yong Liu, Yinghong Zhang, Hao Wu   +3 more
doaj   +1 more source

Enhancing topic clustering for Arabic security news based on k‐means and topic modelling

IET Networks, 2021
The internet has become one of the main sources of news spread as it unleashed the information dissemination space, where the news websites express opinions on entities while also reporting on recent or unusual security risks.
Adel R. Alharbi, Mohammad Hijji, Amer Aljaedi   +2 more
doaj   +1 more source

Computational text analysis

Computational text analysis (CTA) comprises techniques for measuring the content of texts with the help of computer algorithms. The methods are discussed under various labels, such as text-as-data, automated content analysis, natural language processing, or text mining.
Marko Bachl, Michael Scharkow
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Comprehensive Review on Document Image Binarization

Journal of Imaging
In today’s digital age, the conversion of hardcopy documents into digital formats is widespread. This process involves electronically scanning and storing large volumes of documents.
Bilal Bataineh, Mohamed Tounsi, Nuha Zamzami, Jehan Janbi, Waleed Abdel Karim Abu-ain, Tarik AbuAin, Shaima Elnazer   +6 more
doaj   +1 more source

Creating and Testing Specialized Dictionaries for Text Analysis

East European Journal of Psycholinguistics, 2019
Practitioners in many domains–e.g., clinical psychologists, college instructors, researchers–collect written responses from clients. A well-developed method that has been applied to texts from sources like these is the computer application Linguistic ...
Roman Taraban, Jessica Pittman, Taleen Nalabandian, Winson Fu Zun Yang, William M. Marcy, Srivinasa Murthy Gunturu   +5 more
doaj   +1 more source

Text Preprocessing for Speech Synthesis [PDF]

, 2006
In this paper we describe our text preprocessing modules for English text-to-speech synthesis. These modules comprise rule-based text normalization subsuming sentence segmentation and normalization of non-standard words, statistical part-of-speech ...
Pfitzinger, Hartmut R., Reichel, Uwe D., Uwe D. Reichel, Uwe D.Reichel, Hartmut R. Pfitzinger, Hartmut R. Ptzinger   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Systematic Analysis of Speech Transcription Modeling for Reliable Assessment of Depression Severity

Sakarya University Journal of Computer and Information Sciences
For depression severity assessment, we systematically analyze a modular deep learning pipeline that uses speech transcriptions as input for depression severity prediction.
Hamdi Dibeklioğlu, Ergün Batuhan Kaynak   +1 more
doaj   +1 more source