Results 91 to 100 of about 119,353 (308)

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Improving classification in protein structure databases using text mining [PDF]

, 2009
Background: The classification of protein domains in the CATH resource is primarily based on structural comparisons, sequence similarity and manual analysis.
Jones, DT, Koussounadis, A, Oliver C Redfern, Redfern, Oliver, Koussounadis Antonis, Jones David T, Redfern, OC, Redfern Oliver C, Antonis Koussounadis, David T Jones, Jones, David, Koussounadis, Antonis   +11 more
core   +1 more source

Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design

Advanced Science, EarlyView.
A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram, Mohit Chakraborty, Sai Mani Kumar Devathi, B. Pabitramohan Prusty, Rohit Batra   +4 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Knowledge Management for Biomedical Literature: The Function of Text-Mining Technologies in Life-Science Research

, 2008
Efficient information retrieval and extraction is a major challenge in life-science research. The Knowledge Management (KM) for biomedical literature aims to establish an environment, utilizing information technologies, to facilitate better acquisition ...

core   +1 more source

What is Data Mining?

, 2007
owledge presentation, where visualization and knowledge representation techniques are used to present the mined knowledge to the user. With the widely available relational database systems and data warehouses, the first four processes: data cleaning ...
Data Mining
core  

Text mining in a digital library

, 2004
Digital librarians strive to add value to the collections they create and maintain. One way is through selectivity: a carefully chosen set of authoritative documents in a particular topic area is far more useful to those ...
Don, Katherine J., Ian H. Witten, Katherine J. Don, Michael Dewsnip, Tablan, Valentin, Dewsnip, Michael, Valentin Tablan, Witten, Ian H.   +7 more
core   +1 more source

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source

The use of additional evidence in mining usercreated descriptions for content structural design

MATEC Web of Conferences, 2018
The use of a text mining approach for full automatic taxonomy creation for content management has proven with serious limitations. The high level semantics indicating relevant association of entities among the documents are often not explored. This study
Wu Yan
doaj   +1 more source

Disentangling the relationships between denomination of origin regulatory councils activities and Spanish wineries' export performance

Agribusiness, EarlyView.
Abstract World markets for quality differentiated agri‐food products are highly competitive, presenting significant challenges for firms aiming to compete effectively. Government agencies and business organizations often implement various export promotion policies to address these challenges.
Nicolás Depetris‐Chauvin, Marta Fernández‐Olmos   +1 more
wiley   +1 more source