Results 21 to 30 of about 313,332 (246)

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

A Deep and Autoregressive Approach for Topic Modeling of Multimodal Data [PDF]

open access: yes, 2015
Topic modeling based on latent Dirichlet allocation (LDA) has been a framework of choice to deal with multimodal data, such as in image annotation tasks.
Larochelle, Hugo   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Linking Text and Image with SVG [PDF]

open access: yes, 2009
Annotation and linking (or referring) have been described as "scholarly primitives", basic methods used in scholarly research and publication of all kinds.
Cayless, Hugh A.
core  

PubMeth : a cancer methylation database combining text-mining and expert annotation [PDF]

open access: yes, 2008
Epigenetics, and more specifically DNA methylation is a fast evolving research area. In almost every cancer type, each month new publications confirm the differentiated regulation of specific genes due to methylation and mention the discovery of novel ...
M. Ongenaert   +13 more
core   +1 more source

Are chatbots reliable text annotators? Sometimes

open access: yesPNAS Nexus
Abstract Recent research highlights the significant potential of ChatGPT for text annotation in social science research. However, ChatGPT is a closed-source product, which has major drawbacks with regards to transparency, reproducibility, cost, and data protection. Recent advances in open-source (OS) large language models (LLMs) offer an
Ross Deans Kristensen-McLachlan   +4 more
openaire   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Morphological annotation of Korean with Directly Maintainable Resources [PDF]

open access: yes, 2006
This article describes an exclusively resource-based method of morphological annotation of written Korean text. Korean is an agglutinative language. Our annotator is designed to process text before the operation of a syntactic parser.
Berlocher, Ivan   +3 more
core   +5 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Ontology-based Technical Text Annotation [PDF]

open access: yesProceedings of the COLING Workshop on Synchronic and Diachronic Approaches to Analyzing Technical Language, 2014
Powerful tools could help users explore and maintain domain specific documentations, provided that documents have been semantically annotated. For that, the annotations must be sufficiently specialized and rich, relying on some explicit semantic model, usually an ontology, that repre- sents the semantics of the target domain. In this paper, we learn to
François Lévy, Nadi Tomeh, Yue Ma
openaire   +1 more source

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