Results 31 to 40 of about 54,658 (262)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A NOVEL TERM WEIGHTING SCHEME MIDF FOR TEXT CATEGORIZATION [PDF]

Journal of Engineering Science and Technology, 2010
Text categorization is a task of automatically assigning documents to a set of predefined categories. Usually it involves a document representation method and term weighting scheme.
C. DEISY, M. GOWRI, S. BASKAR, S.M.A. KALAIARASI, N. RAMRAJ   +4 more
doaj  

A Customizable Text Classifier for Text Mining

Data Science Journal, 2007
Text mining deals with complex and unstructured texts. Usually a particular collection of texts that is specified to one or more domains is necessary. We have developed a customizable text classifier for users to mine the collection automatically.
Yun-liang Zhang, Quan Zhang
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Defect text recognition and condition assessment method of power equipment based on BERT-BiLSTM [PDF]

PeerJ Computer Science
The accumulated text of power equipment defects in operation are crucial for condition evaluation and maintenance. However, different structures of defect texts and their sensitivity to the experience of operation and maintenance personnel have led to ...
Jian Shao, Xuan Li, Tongbao Liu, Hongzhong Chen, Tonglei Wang, Chao Wei   +5 more
doaj   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Document representations for classification of short web-page descriptions [PDF]

Yugoslav Journal of Operations Research, 2008
Motivated by applying Text Categorization to classification of Web search results, this paper describes an extensive experimental study of the impact of bag-of- words document representations on the performance of five major classifiers - Naïve Bayes ...
Radovanović Miloš, Ivanović Mirjana
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Violence detection explanation via semantic roles embeddings

BMC Medical Informatics and Decision Making, 2020
Background Emergency room reports pose specific challenges to natural language processing techniques. In this setting, violence episodes on women, elderly and children are often under-reported.
Enrico Mensa, Davide Colla, Marco Dalmasso, Marco Giustini, Carlo Mamo, Alessio Pitidis, Daniele P. Radicioni   +6 more
doaj   +1 more source