Results 41 to 50 of about 54,658 (262)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Learning-Free Text Categorization [PDF]
, 2003 In this paper, we report on the fusion of simple retrieval strategies with thesaural resources in order to perform large-scale text categorization tasks. Unlike most related systems, which rely on training data in order to infer text-to-concept relationships, our approach can be applied with any controlled vocabulary and does not use any training data.
Patrick Ruch +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Chinese Text Categorization Based on Multi-Pooling
四川大学学报. 自然科学版, 2017 Text classification is one of the contents of text mining, which has a wide range of applications in the fields of information retrieval, e-mail filtering, web page classification and so on.
YANG Xin, JIANG Wei, LIU Xiao-Ling
doaj
Applied Sciences, 2021 Software bug report classification is a critical process to understand the nature, implications, and causes of software failures. Furthermore, classification enables a fast and appropriate reaction to software bugs. However, for large-scale projects, one
Ömer Köksal, Bedir Tekinerdogan
doaj +1 more source
Query translation by text categorization [PDF]
Proceedings of the 20th international conference on Computational Linguistics - COLING '04, 2004 We report on the development of a cross language information retrieval system, which translates user queries by categorizing these queries into terms listed in a controlled vocabulary. Unlike usual automatic text categorization systems, which rely on dataintensive models induced from large training data, our automatic text categorization tool applies ...
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Authorship Identification of Electronic Texts
IEEE Access, 2021 Electronic text stylometry is concerned with analyzing the writing styles of input electronic texts to extract information about their authors. For example, such extracted data could be the authors’ identity or other aspects, such as their gender ...
Mahmoud Khonji +2 more
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source