Results 81 to 90 of about 41,653,367 (301)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Mosaicing-by-recognition: a technique for video-based text recognition

Eighth International Conference on Document Analysis and Recognition (ICDAR'05), 2005
In this paper, a mosaicing-by-recognition technique is proposed where video mosaicing and text recognition are simultaneously and collaboratively optimized in a one-step manner. Specifically, multiple frames capturing a long text line are optimally concatenated with a guide of the text recognition framework.
Hiromitsu Miyazaki, Seiichi Uchida, Hiroaki Sakoe   +2 more
openaire   +2 more sources

Text+ loves Data

Auch wir lieben bekanntermaßen Daten. Daher ist Text+ natürlich auch bei der diesjährigen Love Data Week dabei, die vom 12. bis 16. Februar stattfindet.
Text+ Blog-Redaktion
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

OSCAR4: a flexible architecture for chemical text-mining. [PDF]

, 2011
The Open-Source Chemistry Analysis Routines (OSCAR) software, a toolkit for the recognition of named entities and data in chemistry publications, has been developed since 2002.
David M Jessop, Peter Murray-Rust, Lezan Hawizy, Sam E Adams, Murray-rust, Peter, Egon L Willighagen, Adams, Sam E, Jessop, David M, Willighagen, Egon L, Hawizy, Lezan   +9 more
core   +5 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Research on vectorization technology for electrical wiring diagrams

Zhejiang dianli
Electrical wiring diagrams， which represent the positions of electrical equipment and describe their wiring and cabling methods， need to be converted into XML for smart grid system scheduling and management.
ZHANG Yong, SONG Aibo, SU Mengmeng, WANG Tianyu, WANG Qingwei, CHEN Rui   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Text+ auf der OPERAS-Konferenz 2024

Autor:innen: Nanette Rißler-Pipka, Angela Vorndran, Philippe Genêt, Eva-Maria Gerstner Bei der kommenden OPERAS conference 2024, die vom 24. bis zum 26.
Text+ Mitglied
core   +1 more source