Results 31 to 40 of about 679,654 (280)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
New Testament textual criticism for non-textual critics - A few suggestions
In die Skriflig, 1987 The need arises now and again for a translator or an exegete with only a basic knowledge of textual criticism to examine a textual problem in order to verify the reading of the text with which he works.
J. H. Petzer, J. C. Jordaan
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Textual Notes on the Latin Odes of Garcilaso de la Vega
Studia Aurea: Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro, 2021 Textual criticism of passages in the Latin odes of Garcilaso de la Vega.
Joseph Duffield Reed
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The relationship between textual criticism and the synoptic question: a study based on the passion narrative [PDF]
, 2005 Since the eighteenth century, various hypotheses have been proposed by scholars in an attempt to solve the Synoptic Question. Most of these scholars have used more or less the same Greek text, yet they have come up with different conclusions.
Chan Chim Yuk, Marc
core
Bayesian Textual Criticism: Evolutionary Genetics and the Transmission of New Testament Texts [PDF]
, 2022 [Note: these are the slides for the second talk described in the abstract.] Phylogenetics is an approach developed in evolutionary biology to reconstruct organisms’ relationships of descent based on observations of their trait similarities and ...
Joey McCollum
core +1 more source
Onlangse konsepte in teksuitleg en hulle konsekwensies vir die (gereformeerde) teologie
In die Skriflig, 1994 Over the past century Old Testament exegesis closely followed developments in the fields of philosophy and theory of literature (e.g. romanticism, historism, phenomenology, stricturalism) and has since the early seventies of this century been ...
F. E. Deist
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source