Results 31 to 40 of about 12,310 (292)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
THE URGENCY OF TEXTUAL CRITICISM OF THE NEW TESTAMENT INERRANCY
, 2022 Textual criticism has long existed as part of the hermeneutic discipline. However, many communities reject this approach. Even scientifically, textual criticism provides a new understanding of the scriptures, especially the New Testament.
Gernaida Krisna R. Pakpahan +1 more
core +1 more source
EURÍPIDES' VERSIFICATION AND TEXTUAL CRITICISM
Myrtia, 2004 As a modest, but I hope didactically useful, appendix to White's paper entitled "Two Philological Notes" I should like to underline a methodological criterion which is, alas, not taken into account by many would-be textual critics.
Guiseppe Giangrande
doaj
Die tekskritiek van die Nuwe Testament (2): �n Oefening in teorie en praktyk
Verbum et Ecclesia, 1992 The textual criticism of the New Testament (2): An exercise in theory and practice This concluding article on New Testament textual criticism focuses on the practical application of a workable method for the evaluation of textual variants in the ...
L. D. Jacobs
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Collocation as a method in textual criticism of Hadith [PDF]
تحقیقات علوم قرآن و حدیث, 2013 Hadith in the process of transmission to the next generations exposed to some damagesincluding,distortion and displacement. This phenomenon necessitate to provide methods in examination and emendation of hadith.
Seyed Kazem Tabatabaeipour +1 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Chronicle of King Gälawdewos (1540–1559): A Critical Edition with Annotated Translation
Aethiopica, 2017 Dissertation ...
Solomon Gebreyes Beyene
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source