Results 41 to 50 of about 3,235 (226)
DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Respiratory Research, 2020 Background Tezepelumab is a human monoclonal antibody that blocks the activity of the epithelial cytokine thymic stromal lymphopoietin. The efficacy, safety and oral corticosteroid-sparing potential of tezepelumab are being investigated in two ongoing ...Andrew Menzies-Gow, Sandhia Ponnarambil, John Downie, Karin Bowen, Åsa Hellqvist, Gene Colice +5 moredoaj +1 more sourceSOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma
Respiratory Research, 2020 Background Many patients with severe asthma continue to experience asthma symptoms and exacerbations despite standard-of-care treatment. A substantial proportion of these patients require long-term treatment with oral corticosteroids (OCS), often at high Michael E. Wechsler, Gene Colice, Janet M. Griffiths, Gun Almqvist, Tor Skärby, Teresa Piechowiak, Primal Kaur, Karin Bowen, Åsa Hellqvist, May Mo, Esther Garcia Gil +10 moredoaj +1 more sourceEffect of Tezepelumab on the Humoral Immune Response to Seasonal Quadrivalent Influenza Vaccination in Patients with Moderate to Severe Asthma: The Phase 3b VECTOR Study
Pulmonary Therapy, 2023 Introduction Annual influenza vaccinations are recommended for adolescents and adults with moderate to severe asthma. This study investigated the effect of tezepelumab, a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, Jeremy Cole, Iwona Cąpała-Szczurko, Stephanie Roseti, Claudia Chen, Scott Caveney, Anastasia A. Aksyuk, Katie Streicher, Sandhia Ponnarambil, Gene Colice +8 moredoaj +1 more sourceTezepelumab treatment for allergic bronchopulmonary aspergillosis
Respirology Case Reports, 2023 AbstractAn 82‐year‐old man had been diagnosed with asthma. He experienced repeated exacerbations requiring treatment with a systemic corticosteroid despite being treated with medications including high‐dose fluticasone furoate/umeclidinium/vilanterol, montelukast sodium, and theophylline; treatment with mepolizumab was then initiated.Hiroaki Ogata, Kachi Sha, Yasuaki Kotetsu, Aimi Enokizu‐Ogawa, Katsuyuki Katahira, Akiko Ishimatsu, Kazuhito Taguchi, Atsushi Moriwaki, Makoto Yoshida +8 moreopenaire +3 more sourcesCASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
Respiratory Research, 2020 Background Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway.Claire Emson, Sarah Diver, Latifa Chachi, Ayman Megally, Cherrie Small, John Downie, Jane R. Parnes, Karin Bowen, Gene Colice, Chris E. Brightling +9 moredoaj +1 more sourceTezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma
, 2023 BACKGROUND
Mucus plugs in asthmatic airways are associated with airway obstruction and the activity of inflammatory cytokines, specifically interleukin (IL)-5 and IL-13, and they may provide an opportunity for targeted therapy.Claire Emson (196258), Jane R Parnes (17065603), Samuel Peterson (6370163), Christopher E Brightling (7668680), Janet M Griffiths (17065597), Celeste Porsbjerg (3155544), Lars H Nordenmark (17065591), John D Newell (8107256), Åsa Hellqvist (17065594), Beata Pawlikowska (17065600), Sarah Diver (7724249), Ayman Megally (17065606), Gene Colice (5129612) +12 morecore +6 more sourcesMonoclonal Antibodies Targeting Alarmins: A New Perspective for Biological Therapies of Severe Asthma
Biomedicines, 2021 Alarmins are innate cytokines, including thymic stromal lymphopoietin (TSLP), interleukin-33 (IL-33), and interleukin-25 (IL-25), which are mainly produced by airway epithelium and exert a prominent role in asthma pathobiology.Corrado Pelaia, Giulia Pelaia, Federico Longhini, Claudia Crimi, Cecilia Calabrese, Luca Gallelli, Angela Sciacqua, Alessandro Vatrella +7 moredoaj +1 more sourceLong-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study.
The Lancet Respiratory Medicine, 2023 BACKGROUND
Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin. The drug has been tested previously in the phase 3 NAVIGATOR (NCT03347279) and SOURCE (NCT03406078) studies, and was subsequently approved as a treatment for ...A. Menzies-Gow, M. Wechsler, C. Brightling, S. Korn, J. Corren, E. Israel, G. Chupp, A. Bednarczyk, S. Ponnarambil, S. Caveney, G. Almqvist, M. Gołąbek, Linda Simonsson, Kaitlyn V J Lawson, K. Bowen, G. Colice, J. Hetzel, J. Fiterman, Adelmir Souza Machado, M. Antila, M. Lima, S. Minamoto, D. Blanco, Patricia Gomes de Matos Bezerra, P. Houle, C. Lemière, L. Melenka, R. Leigh, P. Mitchell, S. Anees, B. Pek, G. Chouinard, A. Cheema, W. Yang, George Philteos, P. Chanez, A. Bourdin, G. Devouassoux, C. Taillé, F. de Blay, C. Leroyer, A. Beurnier, G. Garcia, P. Girodet, F. Blanc, A. Magnan, Stéphanie Wanin, J. Just, Richard Linde, S. Zielen, K. Förster, C. Gessner, M. Jandl, R. Buhl, M. Kornmann, A. Linnhoff, A. Ludwig-Sengpiel, M. Ehlers, T. Schmoller, H.-M. Steffen, M. Hoffmann, J. Kirschner, O. Schmidt, T. Welte, Hilke Temme, O. Wand, A. Bar-Shai, G. Izbicki, N. Berkman, Gershon Fink, D. Shitrit, Y. Adir, P. Kuna, B. Rewerska, Ewa Pisarczyk-Bogacka, O. Kurbacheva, S. L. Mikhaĭlov, M. Vasilev, A. Emelyanov, S. Wali, A. Albanna, R. V. van Zyl-Smit, I. Abdullah, D. Bernhardi, F. Hoosen, E. Irusen, I. Kalla, D. Lakha, E. Mitha, Visvakuren Naidoo, H. Nell, Trevenesan Padayachee, Jeevren Reddy, Friedrich G. Petrick, Eugene van der Walt, Z. F. A. Vawda, Hae-Sim Park, Sang Haak Lee, Mi-kyeong Kim, Jung-Won Park, Y. Cho, Byung Jae Lee, Yoon-Seok Chang, Choon-Sik Park, K. Lee, Sook Young Lee, Hyoungkyu Yoon, Kyoung-Hee Sohn, M. Park, Kyung-Hoon Min, Y. Cho, H. Park, YongChul Lee, Jaechun Lee, C. Sheu, C. Tu, Kang-Yun Lee, S. Bavbek, B. Gemicioglu, D. Ediger, I. Kalkan, N. Makieieva, M. Ostrovskyy, Yevgeniya Dytyatkovs'ka, Y. Mostovoy, Kyrylo Lebed, Oleh S. Yakovenko, Atoya Adams, Timothy S. Mooring, Louis Torres Jr, Marvin Sexton, E. Thompson, J. Bernstein, P. Lisi, Christopher M Chappel, J. Cole, G. Greenwald, Conigliaro Jones, Ryan Klein, D. Pham, S. Spangenthal, S. Weinstein, H. Windom, N. Kao, Mila Leong, V. Mehta, W. Moore, Saligrama B. Bhat, B. Aish, Steve Meltzer, M. Moss, E. Kerwin, J. Delgado, Gregg H. Lucksinger, C. A. Thompson, S. Alpizar, S. Vadgama, Zahid Ali Zafar, J. Jacobs, N. Lugogo, N. Jain, L. Sher, N. Andrawis, D. Fuentes, Eric Boren, E. G. Gonzalez, N. Talreja, S. Durrani, S. Sekhsaria, S. DeLeon, Mayank Shukla, Martha M Totszollosy Tarpay, F. Fakih, G. Hudes, J. Tillinghast, P. Korenblat, K. Shenoy, L. Que, Shahrukh Kureishy, F. C. Umeh, Vinh Phu Nguyen, H. T. Chu, Thuy-Vy Nguyen +182 moresemanticscholar +1 more source
