Results 91 to 100 of about 7,910 (230)

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Evaluation of International Financial Reporting Standards in Terms of Smes-Turkey Application

Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2017
Differences between national accounting practices and international practices make it difficult to compare financial information, create barriers to fundraising processes, and cause difficulties in buying and selling international businesses and mergers.
Murat KARAHAN, Medet İĞDE, Dilek ÖZBEZEK   +2 more
doaj   +1 more source

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong, Shihan Zhang, Chunhua Li, Yufeng Ai, Xinru Liu, Yuxiang Liu, Hongbing Liu   +6 more
wiley   +1 more source

High-compatibility thick-film smart aggregates for strain monitoring of concrete

International Journal of Smart and Nano Materials
Thick-film resistors (TFRs) have shown considerable promise for civil engineering applications due to their high durability, strain sensitivity, and suitability for mass production, thereby fulfilling the long-term monitoring requirements of concrete ...
Ming Wen, Lianjuan Miao, Xinchun Guan
doaj   +1 more source

Novel approaches to the construction of miniaturized analytical instrumentation [PDF]

This paper focuses on the design, construction, preliminary testing, and potential applications of three forms of miniaturized analytical instrumentation.
Bastiaans, Glenn J., Braymen, Steve D., Burns, Stanley G., Coldiron, Shelley J., Deinhammer, Randall S., Deninger, William D., Otoole, Ronald P., Porter, Marc D., Shanks, Howard R.   +8 more
core   +1 more source

BCR–ABL1 Drives Transcriptional Reprogramming of Chronic Myeloid Leukemia Cells for Immune Evasion Through C/EBPβ

MedComm, Volume 7, Issue 5, May 2026.
There is global immunosuppression during CML initiation and progression, which is directly driven by BCR–ABL1 expressing CML cells. On one hand, the BCR–ABL1 oncogene drives the differentiation of leukemia cells toward the neutrophil lineage. On the other hand, the oncogene also transcriptionally activates master immune regulators, including arginase ...
Xiaocui Lu, Hui Fang, Yuan Liu, Chang Liu, Xuexiu Fang, Atsuko Matsunaga, Stephanie F. Mori, Ting Zhang, Gavin Wang, George I. Zhou, Miao Yu, Haocheng Ding, Jorge Cortes, Bo Cheng, Tianxiang Hu   +14 more
wiley   +1 more source

KOBİ TFRS ÇERÇEVESİNDE STOKLARIN MUHASEBELEŞTİRİLMESİ

Afyon Kocatepe Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2012
Türkiye'de faaliyet gösteren işletmelerin büyük çoğunluğunun Küçük ve Orta Büyüklükte İşletme (KOBİ) niteliğinde olması ve çalışan nüfusun büyük bir kısmının söz konusu bu işletmelerde istihdam edilmesi ülke ekonomisi açısından KOBİ'leri önemli hale getirmektedir.
openaire   +3 more sources

‘The Heart of the Matter’: Grandparent Childcare in Contemporary Chinese Families

Children &Society, Volume 40, Issue 3, Page 556-566, May 2026.
ABSTRACT Grandparent childcare is an international phenomenon, especially within families with children under 3 years old. China is no exception, as shown by a number of quantitative studies. Less clear is our understanding of the actual childcare arrangements involved and how these are negotiated and sustained through the intergenerational ...
Jiatong Ling, Lorna Montgomery, John Pinkerton   +2 more
wiley   +1 more source

MÜŞTERİ SADAKAT PROGRAMLARI ve MUHASEBE UYGULAMALARI

Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2014
Müşteri sadakat programları son yıllarda oldukça yaygınlaşmıştır. Birçok işletme müşterilerinin bağlılıklarını sağlamak ve satış hacimlerini artırmak için müşteri sadakat programları uygulamaktadır.
Doç. Dr. Raif Parlakkaya
doaj