Results 81 to 90 of about 4,543 (237)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

A Study on Determination of TFRS (Turkish Financial Reporting Standards )/ TAS (Turkish Accounting Standards) Awareness of Undergraduate Students Receiving Accounting Education

, 2019
Bu araştırma, muhasebe eğitimi alan lisans öğrencilerinin Türkiye Finansal Raporlama Standartları (TFRS) ve Türkiye Muhasebe Standartları (TMS)’ na ilişkin farkındalıklarını belirleme amacı taşımaktadır.
Kezban ŞİMŞEK, ŞİMŞEK, Onur, Onur ŞİMŞEK, ŞİMŞEK, Kezban, Onur ŞİMŞEK, Kezban ŞİMŞEK   +4 more
core   +1 more source

TFRS 15 Müşteri Sözleşmelerinden Hasılat Standardının Otel İşletmeleri Açısından Değerlendirilmesi [PDF]

, 2020
Amaç – Bu çalışma ile otel işletmelerinin hasılat kalemleri, Türkiye Finansal Raporlama Standartları TFRS15 Müşteri Sözleşmelerinden Hasılat boyutuyla ele alınmıştır.
Solmaz, Seyit Ahmet, Ergün, Burcu Çalışkan, Oğuz, Hande Uyar   +2 more
core   +1 more source

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source

TFRS 16 KİRALAMALAR STANDARDININ FİNANSAL GÖSTERGELERE ETKİSİNİN İNCELENMESİ

, 2021
“TFRS 16 Kiralamalar” standardı 31.12.2018 tarihinden sonra başlayan hesap dönemlerinden uygulanmak üzere yürürlüğe girmiştir. Bu çalışmanın amacı, yürürlüğe giren yeni kiralamalar standardının Borsa İstanbul’da (BIST) yer alan işletmelere ve sektörlere ...
Fırat, Faruk Ziya, Baydur, Berker
core   +2 more sources

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

TFRS 14 Düzenlemeye Dayalı Erteleme Hesapları Standardının İrdelenmesi-An Examination of IFRS 14- Regulatory Deferral Accounts

Mehmet Akif Ersoy Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016
Uluslararası Muhasebe Standartları Kurulu 2008 yılından itibaren üzerinde çalıştığı taslakları IFRS 14 Regulatory Deferral Accounts adıyla 1 Ocak 2016’ dan itibaren uygulanmasına başlanacak bir standart olarak yayımlamıştır.
Burcu Aslantaş Ateş
doaj  

Discrete Cosine Transformation and Temporal Adjacent Convolutional Neural Network-Based Remaining Useful Life Estimation of Bearings

Shock and Vibration, 2020
In recent years, several time-frequency representation (TFR) and convolutional neural network- (CNN-) based approaches have been proposed to provide reliable remaining useful life (RUL) estimation for bearings. However, existing methods cannot tackle the
Yu Pang, Limin Jia, Zhan Liu
doaj   +1 more source

Rescaling the Developmental State: Competitive Shrinkage Governance and the Spatial Restructuring of Higher Education in South Korea

Asia Pacific Viewpoint, EarlyView.
ABSTRACT Against the backdrop of sustained demographic contraction across the Asia‐Pacific, the developmental state (DS) paradigm, long premised on growth, faces profound challenges. While existing research on shrinking regions focuses on urban planning, little attention has been paid to how the state restructures its spatial power under contraction ...
Li Mingfeng
wiley   +1 more source

FAİZSİZ FİNANS MUHASEBE STANDARTLARI VE TMS/TFRS KARŞISINDAKİ DURUMU

, 2021
Dini hassasiyetleri gereği, faizi reddeden İslami kesimin elindeki fonların ekonomiyekazandırılabilmesi için uluslararası ölçekte faizsiz finans sistemi oluşturulmuştur.
Utku, Mehmet, Kaya, Yusuf, Yusuf KAYA, Mehmet UTKU   +3 more
core   +1 more source