Results 31 to 40 of about 2,334 (199)

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants [PDF]

Journal of Experimental Medicine, 2014
Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood–brain barrier (BBB) and effectively reduce brain amyloid β levels.
Bien-Ly, Nga, Yu, Y. Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C. Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S., Weimer, Robby M., Chung, Inhee, Watts, Ryan J.   +11 more
openaire   +2 more sources

TFRS 15 Asıl/Vekil Konumlandırması Üzerine Vaka İncelemesi: Turkcell ve Gezinomi

Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2023
Bu çalışma ile Borsa İstanbul’da (BIST) faaliyet gösteren ve iş modeli içerisinde acentelik veya başka bir işletmenin ürün veya hizmetini müşterilerine ulaştırmasında aracılık rolü üstlenerek gelir elde eden işletmelerin TFRS 15’e göre asıl/vekil ...
Soner Gökten, Pınar Okan Gökten, Burak Özdoğan   +2 more
doaj   +1 more source

Analysis of The Impact of Deep Learning-Based Recommendation Algorithms on Demographic Groups [PDF]

ITM Web of Conferences
This study compares the performance of TensorFlow Recommender (TFRS), Light Factorization Machine (LightFM), and Weighted Matrix Factorization (WMF) on the MovieLens 25M dataset.
Niu Jiepeng
doaj   +1 more source

Detection of Non-Stationary GW Signals in High Noise From Cohen’s Class of Time–Frequency Representations Using Deep Learning

IEEE Access, 2022
Analysis of non-stationary signals in a noisy environment is a challenging research topic in many fields often requiring simultaneous signal decomposition in the time and frequency domain.
Nikola Lopac, Franko Hrzic, Irena Petrijevcanin Vuksanovic, Jonatan Lerga   +3 more
doaj   +1 more source

Kurumsal Yönetim İlkelerinin Türkiye Muhasebe Standartlari (TMS) ve Türkiye Finansal Raporlama Standartlari (TFRS) İçindeki Yeri

İzmir İktisat Dergisi, 2019
Son yıllarda artan rekabet ortamı ve yaşanan uluslararası finansal krizler kurumsal yönetim ilkelerinin işletmeler için önemini arttırmıştır. Gerek uluslararası alanda gerek Türkiye’de kurumsal yönetim ilkelerin işletme yönetimlerinde önemli değişiklik ...
Zülkif Yalçın, Meltem Yoluk
doaj   +1 more source

Muhasebe Meslek Mensuplarının Kobi TFRS Hakkındaki Düşünceleri Ve Farkındalık Düzeyleri: Gaziantep Örneği

Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2017
Uluslararası Muhasebe Standartları Kurulu (UMSK) 2009 yılında küçük ve orta büyüklükteki kuruluşların (KOBİ) ihtiyaçları doğrultusunda hazırlanan Uluslararası Mali Raporlama Standardını yayımlamıştır (KOBİ UFRS).
Murat KARAHAN
doaj   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

TFR & the tree of knowledge

III-Vs Review, 1995
AbstractIf III-Vs Review could be described as the trunk in our growing “tree of knowledge” in the field of compound semiconductors then May saw the culmination of our second “branch”, a conference produced in association with III-Vs Review: LDSD95, Singapore — see initial report in this issue.
openaire   +1 more source

Building a Secure Scheme for a Trusted Hardware Sharing Environment

IEEE Access, 2017
Trusted hardware sharing (THS) system can provide multiple trusted execution environments (TEE) via sharing the trusted hardware (e.g., sharing trusted platform module via virtualization) for stand-alone and isolation scenarios.
Di Lu, Jianfeng Ma, Cong Sun, Qixuan Wu, Zhaochang Sun, Ning Xi   +5 more
doaj   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source