Results 81 to 90 of about 4,304 (247)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Temel Finansal Araçların KOBİ TFRS, Tam Set TFRS ve Türk Vergi Mevzuatı ile Karşılaştırmalı İncelenmesi ve Muhasebeleştirme Örnekleri 1

, 2014
Bu çalışmada temel finansal araç lar Tam Set TFRS, KOBİ TFRS ve Türk Vergi Mevzuatıile karşılaştırmalı olarak incelenmiş ve muhasebeleştirme örnekleri ile birlikte açıklanmıştır.Çalışmada, temel finansal araçların sınıflandırma, değerleme ...
ABDİOĞLU, HASAN, GÜNEŞ, Serdar, İŞGÜDEN KILIÇ, BURCU   +2 more
core  

Konsolide finansal tablolar standardının (TFRS 10) incelenmesi [PDF]

, 2015
Tez (Yüksek Lisans) -- İstanbul Ticaret Üniversitesi -- Kaynakça var.Bu çalışmanın amacı, Uluslararası Finansal Raporlama Standartları 10 ve onun resmi tercümesi Türkiye Finansal Raporlama Standartları 10 - Konsolide Finansal Tablolar Standardını kontrol
Savaşkan, Demet Emine
core   +1 more source

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source

On the multifaceted impact of migration on the fertility of receiving countries: Methodological insights and contemporary evidence for Europe, the United States, and Australia

Demographic Research, 2019
Background: Within the context of increasing migration flows and persisting low fertility rates in more developed areas, focus has been placed on the impact of migration on the fertility of receiving countries. Objective: The paper examines the effect
Christos Bagavos
doaj   +1 more source

Discrete Cosine Transformation and Temporal Adjacent Convolutional Neural Network-Based Remaining Useful Life Estimation of Bearings

Shock and Vibration, 2020
In recent years, several time-frequency representation (TFR) and convolutional neural network- (CNN-) based approaches have been proposed to provide reliable remaining useful life (RUL) estimation for bearings. However, existing methods cannot tackle the
Yu Pang, Limin Jia, Zhan Liu
doaj   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

TFRS 14 Düzenlemeye Dayalı Erteleme Hesapları Standardının İrdelenmesi-An Examination of IFRS 14- Regulatory Deferral Accounts

Mehmet Akif Ersoy Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016
Uluslararası Muhasebe Standartları Kurulu 2008 yılından itibaren üzerinde çalıştığı taslakları IFRS 14 Regulatory Deferral Accounts adıyla 1 Ocak 2016’ dan itibaren uygulanmasına başlanacak bir standart olarak yayımlamıştır.
Burcu Aslantaş Ateş
doaj  

Spatial and Temporal Regulation of Receptor Endocytosis in Neuronal Dendrites Revealed by Imaging of Single Vesicle Formation

Cell Reports, 2017
Endocytosis in neuronal dendrites is known to play a critical role in synaptic transmission and plasticity such as long-term depression (LTD). However, the inability to detect endocytosis directly in living neurons has hampered studies of its dynamics ...
Morgane Rosendale, Damien Jullié, Daniel Choquet, David Perrais   +3 more
doaj   +1 more source