Results 21 to 30 of about 7,691 (171)

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, EarlyView.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

The Calibration of the WISE W1 and W2 Tully-Fisher Relation [PDF]

, 2014
In order to explore local large-scale structures and velocity fields, accurate galaxy distance measures are needed. We now extend the well-tested recipe for calibrating the correlation between galaxy rotation rates and luminosities -- capable of ...
Courtois, Hélène, Jarrett, T. H., Masci, Frank J., Neill, J. D., Scowcroft, Victoria, Seibert, Mark, Sorce, Jenny G., Tully, R. Brent   +7 more
core   +4 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Evaluating the Impact of Cellulose Nanocrystals on the Performance of Polycarbonate Thin‐Film Nanocomposite Membranes for Treating Oily Wastewater

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT A new type of thin‐film nanocomposite (TFN) membrane was synthesized by incorporating cellulose nanocrystals (CNCs) into a polyvinyl alcohol (PVA) top layer on a polycarbonate (PC) substrate via dip‐coating. The synthesized TFC and TFN membranes (PC/PVA TFC and PC/PVA‐CNC TFN membranes) were evaluated using contact angle measurement, field ...
Habib Etemadi, Naser Ghasemian, Homayun Khezraqa, Solmaz Tozihi, Seyed Mehdi Sajjadi, Omid Ahmadi   +5 more
wiley   +1 more source

Formation of S0 galaxies through mergers. Evolution in the Tully-Fisher relation since $z\sim1$

, 2017
(Abridged version) We explore whether a scenario that combines an origin by mergers at $z\sim$1.8-1.5 with a subsequent passive evolution of the resulting S0 remnants since $z \sim$0.8-1 is compatible with observational data of S0s in the Tully-Fisher ...
Aceves, Héctor, Borlaff, Alejandro, Eliche-Moral, M. Carmen, Querejeta, Miguel, Rodríguez-Pérez, Cristina, Tapia, Trinidad   +5 more
core   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Anomalous fluctuation relations [PDF]

, 2013
We study Fluctuation Relations (FRs) for dynamics that are anomalous, in the sense that the diffusive properties strongly deviate from the ones of standard Brownian motion. We first briefly review the concept of transient work FRs for stochastic dynamics
Alemany, Balescu, Barkai, Barthelemy, Baule, Beck, Bochkov, Bochkov, Boksenbojm, Bouchaud, Brilliantov, Brockmann1, Bustamante, Bénichou, Bödeker, Campisi, Chaudhury, Chechkin, Ciliberto, Crooks, Dieterich, Douarche, Dunn, Esposito, Esposito, Eule, Evans, Evans, Evans, Evans, Fogedby, Friedl, Gallavotti, Gallavotti, Gallavotti, Gorenflo, Harris, Harris, Hartmann, Hatano, Hayashi, Jaksic, Jarzynski, Jarzynski, Jarzynski, Jepps, Klafter, Klafter, Klages, Klages, Kubo, Kubo, Kukla, Kurchan, Lauffenburger, Li, Lutz, Lämmermann, Mai, Martin, Metzler, Metzler, Metzler, Metzler, Ohkuma, Panja, Podlubny, Porra, Risken, Ritort, Rondoni, Sagawa, Samko, Samorodnitsky, Scalas, Scher, Schneider, Seifert, Seifert, Sellitto, Semmrich, Shlesinger, Sokolov, Solomon, Song, Stokes, Takagi, Taloni, Touchette, Touchette, Toyabe, Upadhyaya, Van den Broeck, van Zon, van Zon, Viswanathan, Wang, Zamponi, Zamponi   +98 more
core   +1 more source

Interleukin‐2 deprived state of regulatory T cells and their recovery by low‐dose interleukin‐2 in patients with inflammatory myopathies

Arthritis &Rheumatology, Accepted Article.
Objective Regeneration and expansion of regulatory T cells (Treg) by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg‐IL‐2 axis emerge in ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

The evolving role of regulatory T cells in Sjögren's disease pathogenesis and the promise of Treg‐based therapies: A comprehensive review

Rheumatology &Autoimmunity, EarlyView.
Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs, Bharath Raj Srinivasan, Himabindu Jayaprakash Narayan, Mirunalini Gobinath, Lekitha Manjunath, Mahabaleshwar Mamadapur   +5 more
wiley   +1 more source