Results 71 to 80 of about 2,337 (203)

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

TFRS 14 Düzenlemeye Dayalı Erteleme Hesapları Standardının İrdelenmesi-An Examination of IFRS 14- Regulatory Deferral Accounts

Mehmet Akif Ersoy Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016
Uluslararası Muhasebe Standartları Kurulu 2008 yılından itibaren üzerinde çalıştığı taslakları IFRS 14 Regulatory Deferral Accounts adıyla 1 Ocak 2016’ dan itibaren uygulanmasına başlanacak bir standart olarak yayımlamıştır.
Burcu Aslantaş Ateş
doaj  

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukaemia in the chronic phase: Result of the Japan Adult Leukemia Study Group RE‐STOP219 study

British Journal of Haematology, EarlyView.
Summary Treatment‐free remission (TFR) is now a key goal for chronic‐phase chronic myeloid leukaemia (CML‐CP) after achievement of a prolonged deep molecular response. About half of these patients can remain in remission without treatment, whereas those who relapse must resume lifelong therapy.
Noriyoshi Iriyama, Naoto Takahashi, Katsumichi Fujimaki, Takaaki Ono, Masuho Saburi, Masahide Yamamoto, Fumihiko Kimura, Eisei Kondo, Nobuyuki Aotsuka, Hiroki Yokoyama, Seiichiro Katagiri, Yosuke Minami, Maho Ishikawa, Yachiyo Kuwatsuka, Masatomo Miura, Akiko M. Saito, Toshiki I. Saito, Itaru Matsumura, Yasushi Miyazaki, Emiko Sakaida, Yoshinobu Maeda, Takahiro Yamauchi, Hitoshi Kiyoi   +22 more
wiley   +1 more source

Adapting UK Clinical Practise in Chronic Myeloid Leukaemia in Chronic Phase to Contemporary Management Recommendations: The ADAPT 2.0 Survey

European Journal of Haematology, EarlyView.
ABSTRACT Objective Chronic myeloid leukaemia in chronic phase (CML‐CP) treatment recommendations have changed substantially in recent years. The ADAPT 2.0 survey aimed to provide an updated understanding of CML‐CP management in the UK. Methods This healthcare professional (HCP) survey, conducted between December 2023 and June 2024, assessed treatment ...
Dragana Milojkovic, Nicholas C. P. Cross, Ketul Desai, Kathryn Frewin, Mhairi Copland   +4 more
wiley   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Investigation of Different CNN-Based Models for Improved Bird Sound Classification

IEEE Access, 2019
Automatic bird sound classification plays an important role in monitoring and further protecting biodiversity. Recent advances in acoustic sensor networks and deep learning techniques provide a novel way for continuously monitoring birds.
Jie Xie, Kai Hu, Mingying Zhu, Jinghu Yu, Qibing Zhu   +4 more
doaj   +1 more source

Do Environmentalists Forgo Parenthood? A Life Course Perspective on Fertility Expectations and Behaviors in the UK

Journal of Marriage and Family, EarlyView.
ABSTRACT Objective To assess whether environmental concerns are associated with fertility expectations and behaviors across the reproductive life course. Background Whether individuals consider climate change in their reproductive decisions is an emerging area of research.
Katya Ivanova, Tobias Rüttenauer
wiley   +1 more source

If Not Now, When? Thinking about Childbearing in Ukrainian Cities during Russia's Full‐Scale Invasion

Population and Development Review, EarlyView.
Abstract Prior literature on fertility during war examines high‐fertility settings using quantitative data on births collected mainly after fighting ends. In contrast, we analyze cognitive processes related to childbearing during wartime in Ukraine, where a full‐scale war erupted in the context of long‐standing low fertility.
Anna Popovych, Brienna Perelli‐Harris, Theodore P. Gerber   +2 more
wiley   +1 more source