Results 121 to 130 of about 4,304 (247)
Dimensional and geometric parameters of microstructure models for thick resistive films
The similarities and differences in the dimensional and geometric parameters of microstructure models for silver-palladium thick-film resistors (TFRs) are analyzed. For the first time, using the structural model of metallic clusters and the cluster model
A. V. Sterkhova
doaj
Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley +1 more source
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Abstract Relapsed/refractory (R/R) B‐cell lymphomas (B‐NHL) remain incurable, with limited predictive biomarkers to guide immunotherapy. Preclinical platforms that faithfully preserve the immune context and the viability of patient samples are critically needed for relevant high‐throughput drug testing.
Fabien Gava +20 more
wiley +1 more source
Küresel ekonomik düzen açısından olduğu kadar Türkiye ekonomisi için de büyük önem taşıyan ve yaygın şekilde kullanılan fason üretim tekstil ve konfeksiyon sektöründe sıkça tercih edilen bir üretim sistemidir.
Durmuş, Veli
core +1 more source
ABSTRACT Background and Aims Fertility is a fundamental demographic indicator with important implications. Identifying the characteristics associated with different fertility levels and developing reliable predictive models may provide valuable evidence for population and reproductive health planning.
Sadia Akter Sumi +3 more
wiley +1 more source
Comparison of Measurement and Accounting Principles of Stock Costs for TPL, TAS/TFRS and LFRF Drfat
İşletmelerin dönen varlıkları içerisinde önemli bir yere sahip olan stokların ölçme ve muhasebeleştirmesine yönelik olarak VUK ve TMS/TFRS arasında belirgin farklılıklar bulunmaktadır.
Öztürk, Erkan, Erkan Öztürk
core +1 more source
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source
Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang +10 more
wiley +1 more source

