Results 51 to 60 of about 634,529 (208)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

UN CAZ RAR DE INFECŢIE DE TRACT URINAR CU BURKHOLDERIA CEPACIA LA VÂRSTĂ PEDIATRICĂ [PDF]

open access: yesRomanian Journal of Infectious Diseases, 2018
Introducere. Burkholderia cepacia este un bacil aerob, gram negativ care nu fermentează glucoza, ce afectează în primul rând pacienţii imunocomprimaţi sau spitalizaţi.
Iulia Armean   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

SEPSIS CU PNEUMOCOC LA UN COPIL CU SINDROM NEFROTIC [PDF]

open access: yesRomanian Journal of Infectious Diseases, 2018
Introducere. Sindromul nefrotic reprezintă una dintre cele mai frecvente patologii glomerulare întâlnită la vârsta pediatrică, având o incidenţă de 4,7 cazuri la 100.000 de copii.
Iulia Armean   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Study of Isthmin-1 Levels and Serum Lipid Measurements in Patients with Metabolic Syndrome

open access: yesMedical Journal of Babylon
Background: Metabolic syndrome (MetS) is a group of comorbidities that includes obesity, hypertension, and disturbances in carbohydrate and lipid metabolism. Isthmin-1 (ISM1) is a secreted protein that plays multiple roles in pathophysiological processes.
Suhair Abdul Raheem Ahmed   +1 more
doaj   +1 more source

TG&Y Office Employees' Bulletin

open access: yes, 1969
Newsletter published for employees of T. G. & Y.
TG & Y (Firm)
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

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