Results 51 to 60 of about 1,428,737 (283)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A case-control study of the lipid profile of women with breast cancer

Journal of Education, Health and Sport, 2020
Purpose: Neoplastic diseases remain the second most common cause of death, behind cardiovascular diseases, and breast cancer is the leading cause of death among women worldwide.
Katarzyna Piasecka, Andrzej Stanisławek, Elżbieta Stasiak, Anna Irzmańska-Hudziak, Katarzyna Kociuba-Adamczuk   +4 more
doaj   +1 more source

TG-Hyperbolicity of virtual links [PDF]

Journal of Knot Theory and Its Ramifications, 2019
We extend the theory of hyperbolicity of links in the 3-sphere to tg-hyperbolicity of virtual links, using the fact that the theory of virtual links can be translated into the theory of links living in closed orientable thickened surfaces. When the boundary surfaces are taken to be totally geodesic, we obtain a tg-hyperbolic structure with a unique ...
Colin Adams, Or Eisenberg, Jonah Greenberg, Kabir Kapoor, Zhen Liang, Kate O’Connor, Natalia Pacheco-Tallaj, Yi Wang   +7 more
openaire   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Research on low density polyethylene (LDPE), recycled by advanced thermal analysis (DSC, TG)

International Journal of Applied Mechanics and Engineering, 2023
This article presents the issue of recycling and maintaining the processing properties of materials made of plastics. For this purpose, samples from recycled, low-density, polyethylene were tested.
Bartosz Siwczyk, Paweł Schlafka, Michał Sąsiadek, Waldemar Woźniak   +3 more
doaj   +1 more source

One Dimensional Magnetized TG Gas Properties in an External Magnetic Field

, 2009
With Girardeau's Fermi-Bose mapping, we have constructed the eigenstates of a TG gas in an external magnetic field. When the number of bosons $N$ is commensurate with the number of potential cycles $M$, the probability of this TG gas in the ground state ...
An Min Wang, Blanch G, del Campo A, Dingle R B, Pitaevskii L, Zhao Liang Wang   +5 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Combined effects of restriction factors and transduction adjuvants on lentiviral vector gene transfer efficacy

Scientific Reports
Restriction factors include various cellular proteins that detect and impede viral infections. Among them, interferon-induced transmembrane (IFITM) and serine incorporator (SERINC) proteins interfere with the infectious cycle of HIV-1. Consequently, such
Marie Dewannieux, Fatoumata Fofana, Kathleen Hamon, Mirella Mormin, Anne Galy   +4 more
doaj   +1 more source

Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Several studies have reported that commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum High Density Lipoproteins Cholesterol (HDL-C) levels, while some others documented no such effect.
K. Manimekalai, B. Visakan, Kartik J. Salwe, S. Murugesan   +3 more
doaj   +1 more source