Results 101 to 110 of about 270,164 (307)

The pituitary TGFb1 system as a novel target for the treatment of resistant prolactinomas [PDF]

, 2016
Prolactinomas are the most frequently observed pituitary adenomas and most of themrespond well to conventional treatment with dopamine agonists (DAs).
Camilletti, María Andrea, Diaz, Graciela Susana, Recouvreux, Maria Victoria, Rifkin, Daniel B.   +3 more
core   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Using the interplay of magnetic guidance and controlled TGF-β release from protein-based nanocapsules to stimulate chondrogenesis

International Journal of Nanomedicine, 2018
Chih-Sheng Chiang,1 Jian-Yi Chen,1 Min-Yu Chiang,1 Kai-Ting Hou,1 Wei-Ming Li,1 Shwu-Jen Chang,2 San-Yuan Chen11Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan; 2Department of Biomedical Engineering, I ...
Chiang CS, Chen JY, Chiang MY, Hou KT, Li WM, Chang SJ, Chen SY   +6 more
doaj  

Evaluation of transforming growth factor-beta 1 concentrations in serum, peritoneal and endometrioma fluid in women operated on for ovarian endometriosis as a biomarker of endometrioma

Ginekologia Polska
OBJECTIVES: Some studies indicate the role of transforming growth factor-beta 1 (TGF-beta 1) in the development of endometriosis. However, the lack is studies assessed its plasma levels as a biomarker of endometrioma.
Mariusz Wojtowicz, Dariusz Zdun, Aleksander J. Owczarek, Violetta Skrzypulec-Plinta, Magdalena Olszanecka-Glinianowicz   +4 more
doaj   +1 more source

Structure Identification of ViceninII Extracted from Dendrobium officinale and the Reversal of TGF-β1-Induced Epithelial–Mesenchymal Transition in Lung Adenocarcinoma Cells through TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways

Molecules, 2019
ViceninII is a naturally flavonoid glycoside extracted from Dendrobium officinale, a precious Chinese traditional herb, has been proven to be valuable for cancer treatment.
Yingyi Luo, Zhiyao Ren, Biaoyan Du, Shangping Xing, Shaowei Huang, Yunrong Li, Zhouxi Lei, Dan Li, Huanhuan Chen, Yuechun Huang, Gang Wei   +10 more
doaj   +1 more source

A renin-angiotenzin rendszer szerepe a csontátépülés szabályozásában = The role of the renin-angiotensin system in the regulation of bone-remodelling [PDF]

, 2007
Számos humorális faktor veszt részt a csontszöveti remodelling szabályozásában. Feltételeztük, hogy a szöveti renin-angiotenzin rendszer (RAS) és a transforming growth factor (TGF)-beta is hatással van az osteoblastok funkciójára.
Fintha, Attila, Huszár, Tamás, Masszi, András, Terebessy, Tamás   +3 more
core  

Systems theory of Smad signaling

, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the ...
Alves, Alves, Barkai, Battogtokh, Brightman, Brown, Brown, Chacko, Chen, Colland, Conery, D.C. Clarke, Derynck, Dong, Fink, Funaba, Fung, Gardner, Hager, Haugh, Hoffmann, Huang, Inman, Inman, Jayaraman, Kawabata, Kholodenko, Kim, Lagna, Lander, Lee, Liu, M.D. Betterton, Massague, Massague, Massague, Nakao, Nakao, Nicolas, Nicolas, Park, Pasche, Pierreux, Poncelet, Remy, Schmierer, Schoeberl, Sedaghat, Shi, Shi, Subramanian, ten Dijke, Tewari, Tian, Tsukazaki, Vilar, von Dassow, Wu, X. Liu, Xu, Xu, Yamada, Zhang, Zi   +63 more
core   +1 more source

Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium [PDF]

, 2011
Background: Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling pathways and genes in this process ...
Chambers, Karen F., Pearson, Joanna F., Pellacani, Davide, Aziz, Naveed, Gužvić, Miodrag, Klein, Christoph A., Lang, Shona H.   +6 more
core   +4 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers [PDF]

, 2014
[Image: see text] TGF-β1, -β2, and -β3 are small, secreted signaling proteins. They share 71–80% sequence identity and signal through the same receptors, yet the isoform-specific null mice have distinctive phenotypes and are inviable.
Andrew P. Hinck, Archer S. J., Archer S. J., Baardsnes J., Baker S. M., Bandyopadhyay B., Biernacka A., Bocharov E. V., Bocharov E. V., Cheifetz S., Daopin S., Deep S., Delaglio F., Eghbalnia H. R., Freedberg D. I., Gato A., Goddard T. D., Groppe J., Grutter C., Grzesiek S., Grzesiek S., Hall B. E., Hart P. J., Hinck A. P., Hinck A. P., Huang T., Kay L. E., Kay L. E., Kulkarni A. B., Liu Q., Loeys B. L., Lopez-Casillas F., Marley J., Massague J., Massague J., Massague J., Mendoza V., Mittl P. R., Moustakas A., Munoz V., Munoz V., Nilsen-Hamilton M., Pellaud J., Proetzel G., Qian S. W., Radaev S., Sanford L. P., Schlunegger M. P., Schor S. L., Seth L. Schor, Shah M., Shi Y., Shull M. M., Tao Huang, Taya Y., Tudela C., Wittekind M., Wrana J. L., Wrana J. L., Yang L. T., Zou Z., Zuniga J. E.   +61 more
core   +2 more sources