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Staphylococcus aureus regulates Th17 cells and autophagy via STING in chronic eosinophilic rhinosinusitis with nasal polyps. [PDF]
Eur Arch OtorhinolaryngolGan W, Liu X, Liu F, Hu J.
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International Immunopharmacology, 2011
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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Nature Reviews Immunology, 2020
Febrile temperature increases the differentiation of T helper 17 (TH17) cells with a more pro-inflammatory, pathogenic phenotype, which could have implications for the pathogenesis of autoimmunity.
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Febrile temperature increases the differentiation of T helper 17 (TH17) cells with a more pro-inflammatory, pathogenic phenotype, which could have implications for the pathogenesis of autoimmunity.
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Current Molecular Medicine, 2008
Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
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Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
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Annual Review of Immunology, 2009
CD4+T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
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CD4+T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
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2011
CD4+ T helper (TH) lymphocytes represent a heterogeneous population of cells that play an essential role in adaptive immunity. In addition to type 1 (TH1) and type 2 (TH2) cells, a third subset of CD4+ TH effector cells have recently been discovered and named as type 17 (TH17), because of its unique ability to produce interleukin (IL)-17.
Francesco Annunziato +4 more
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CD4+ T helper (TH) lymphocytes represent a heterogeneous population of cells that play an essential role in adaptive immunity. In addition to type 1 (TH1) and type 2 (TH2) cells, a third subset of CD4+ TH effector cells have recently been discovered and named as type 17 (TH17), because of its unique ability to produce interleukin (IL)-17.
Francesco Annunziato +4 more
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Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases
Science China Life Sciences, 2020Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate.
Guan, Yang, Yaoyao, Xia, Wenkai, Ren
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Th17 cells in autoimmune diseases
Frontiers of Medicine, 2015Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases.
Lei, Han +5 more
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TH17 cells thirsty for calcium
Nature Reviews Immunology, 2019Stefan Feske and colleagues show that calcium signalling in TH17 cells promotes a pathogenic phenotype by regulating mitochondrial function and the antioxidant response.
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Th17 Cells in Cardiovascular Disease
Cell Biochemistry and FunctionABSTRACTRecent research has shown a strong link between Th17 cells and their cytokine IL‐17, and various cardiovascular diseases such as atherosclerosis, myocardial infarction, myocarditis, and arrhythmia. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease.
Ke Yang +7 more
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