Results 1 to 10 of about 49,810 (235)

Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis [PDF]

Frontiers in Immunology
Macrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells can
Alexander Muselman, Lewis W. Yu, Khoa D. Nguyen, Mohammed Inayathullah, Qiang Liu, Kyle D. Brewer, Andrey V. Malkovskiy, Jayakumar Rajadas, Jayakumar Rajadas, Edgar G. Engleman, Edgar G. Engleman   +10 more
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Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]

Brain and Behavior
Objective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song, Bin Li, Ruoyi Guo, Yi Zhou, Yumei Xue, Li Guo   +5 more
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Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.

PLoS ONE, 2019
Antibodies, including antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1, have been shown to contribute to the pathogenesis of multiple sclerosis, thus it is important to assess their biological activity using animal models ...
Sangmin Lee, Hannah E Salapa, Michael C Levin   +2 more
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B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis [PDF]

Cellular and Molecular Life Sciences
N6-methyladenosine (m6A), the most prevalent RNA modification, plays a pivotal role in regulating mRNA metabolism and cellular processes such as immune responses.
Xuzhong Pei, Xiying Wang, Jie Ding, Haojun Yu, Chunran Xue, Chong Xie, Yi Chen, Xinyu Lin, Hong Yang, Yangtai Guan   +9 more
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Expression of components involved in cholesterol homeostasis maintenance during experimental autoimmune encephalomyelitis in rat spinal cord

Folia Neuropathologica
Dysregulations in cholesterol homeostasis contribute to the pathogenesis of multiple sclerosis (MS) and its best described animal model, experimental autoimmune encephalomyelitis (EAE).
Smilja Todorovic, Katarina Milosevic, Ana Milosevic, Marija M. Janjic, Srdjan J. Sokanovic, Danijela Savic, Irena Lavrnja   +6 more
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Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

EMBO Molecular Medicine, 2014
Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler, Sarah Mundt, Tony Muchamuel, Carlo Moll, Jing Jiang, Marcus Groettrup, Christopher J. Kirk   +6 more
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Translational utility of experimental autoimmune encephalomyelitis: recent developments

Journal of Inflammation Research, 2015
Andre Ortlieb Guerreiro-Cacais, Hannes Laaksonen, Sevasti Flytzani, Marie N'diaye, Tomas Olsson, Maja Jagodic Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Abstract:
Guerreiro-Cacais AO, Laaksonen H, Flytzani S, N’diaye M, Olsson T, Jagodic M   +5 more
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Evaluation of methods of modeling and formation of experimental allergic encephalomyelitis [PDF]

Research Results in Pharmacology, 2022
Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Oleksandr O. Nefodov, Igor F. Belenichev, Mykola P. Fedchenko, Olena O. Popazova, Victor P. Ryzhenko, Oksana V. Morozova   +5 more
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MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis

Neural Regeneration Research, 2020
Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
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Should mast cells be considered therapeutic targets in multiple sclerosis?

Neural Regeneration Research, 2020
Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis.
Karen Henriette Pinke, Sofia Fernanda Gonçalves Zorzella-Pezavento, Vanessa Soares Lara, Alexandrina Sartori   +3 more
doaj   +1 more source