Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis [PDF]
Frontiers in ImmunologyMacrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells can
Alexander Muselman +10 more
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Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]
Brain and BehaviorObjective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song +5 more
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B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis [PDF]
Cellular and Molecular Life SciencesN6-methyladenosine (m6A), the most prevalent RNA modification, plays a pivotal role in regulating mRNA metabolism and cellular processes such as immune responses.
Xuzhong Pei +9 more
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Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler +6 more
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Evaluation of methods of modeling and formation of experimental allergic encephalomyelitis [PDF]
Research Results in Pharmacology, 2022 Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Oleksandr O. Nefodov +5 more
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Neural Regeneration Research, 2020 Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
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Should mast cells be considered therapeutic targets in multiple sclerosis?
Neural Regeneration Research, 2020 Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis.
Karen Henriette Pinke +3 more
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Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]
PLoS ONE, 2013 Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris +7 more
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Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]
PLoS ONE, 2013 Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz +10 more
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Silencing miR-150 Ameliorates Experimental Autoimmune Encephalomyelitis
Frontiers in Neuroscience, 2018 MiR-150 regulates maturation and differentiation of T cells but how it functions in multiple sclerosis (MS) is unclear. In miR-150 knockout (KO) mice, we examined the effect of miR-150 deletion on disease severity of experimental autoimmune ...
Zhaolan Hu +8 more
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