Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis [PDF]
Frontiers in ImmunologyMacrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells can
Alexander Muselman +10 more
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Peptide immunotherapy in experimental autoimmune encephalomyelitis
Biomedical Journal, 2015 We now have potent drugs available to treat the inflammatory component of multiple sclerosis (MS). However, not all patients respond, the drugs are not curative, and the associated risks to beneficial immune surveillance are considerable.
Stephen M Anderton
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A2 astrocyte polarization mediates ketogenic diet protection of blood–central nervous system barriers in experimental autoimmune encephalomyelitis [PDF]
Neural Regeneration ResearchDisruption of the blood–brain barrier and blood-spinal cord barrier is a fundamental pathological feature of multiple sclerosis progression. The ketogenic diet has a high therapeutic potential for patients with multiple sclerosis.
Qianye Zhang +5 more
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Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]
PLoS ONE, 2013 Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris +7 more
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Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]
PLoS ONE, 2013 Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz +10 more
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Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]
Brain and BehaviorObjective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song +5 more
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Experimental autoimmune encephalomyelitis
Biomedical Journal, 2015 Jean Kanellopoulos
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Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler +6 more
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B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis [PDF]
Cellular and Molecular Life SciencesN6-methyladenosine (m6A), the most prevalent RNA modification, plays a pivotal role in regulating mRNA metabolism and cellular processes such as immune responses.
Xuzhong Pei +9 more
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Gliotoxin Aggravates Experimental Autoimmune Encephalomyelitis by Triggering Neuroinflammation
Toxins, 2019 Gliotoxin (GTX) is the major and the most potent mycotoxin that is secreted by Aspergillus fumigatus, which is capable of injuring and killing microglial cells, astrocytes, and oligodendrocytes.
Thais Fernanda de Campos Fraga-Silva +7 more
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