Results 31 to 40 of about 6,369,773 (275)

AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

Journal of Experimental Medicine, 2021
In this study, Ma et al. demonstrate that AIM2 negatively regulates the DNA-PK–AKT3 in microglia to control neuroinflammation synergistically induced by cGAS and DNA-PK, thereby preventing the pathogenesis of EAE independent of inflammasome activation.
Chun-Mei Ma, Sheng Li, Ying-Chao Hu, Yan Ma, Yu-Qing Wu, Chunyan Wu, Xue Liu, Bing-Wei Wang, Gang Hu, Jia-wei Zhou, Shuo Yang   +10 more
semanticscholar   +1 more source

Experimental Autoimmune Encephalomyelitis in the Mouse [PDF]

Current Protocols in Immunology, 1996
Abstract This unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Stephen D, Miller, William J, Karpus
openaire   +2 more sources

MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis

Neural Regeneration Research, 2020
Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
doaj   +1 more source

Should mast cells be considered therapeutic targets in multiple sclerosis?

Neural Regeneration Research, 2020
Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis.
Karen Henriette Pinke, Sofia Fernanda Gonçalves Zorzella-Pezavento, Vanessa Soares Lara, Alexandrina Sartori   +3 more
doaj   +1 more source

Peptide-based immunotherapy of experimental autoimmune encephalomyelitis without anaphylaxis [PDF]

, 2007
Administration of peptide antigens in tolerogenic form holds promise as a specific treatment for autoimmune and allergic disorders. However, experiments in rodent autoimmune models have highlighted the risk of anaphylaxis in response to systemic peptide ...
Stephen M. Anderton, Chung, Chen-Yen, Culshaw, Abigail, Leech, Melanie D, Chen-Yen Chung, Anderton, Stephen M, Abigail Culshaw, Melanie D. Leech   +7 more
core   +1 more source

Cytokines and Chemokines in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Journal of Immunology, 2020
Experimental autoimmune encephalomyelitis is a CD4+ T cell–mediated demyelinating disease of the CNS that serves as a model for multiple sclerosis. Cytokines and chemokines shape Th1 and Th17 effector responses as well as regulate migration of leukocytes
W. Karpus
semanticscholar   +1 more source

The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis [PDF]

, 2006
Innate immune receptors are crucial for defense against microorganisms. Recently, a cross-talk between innate and adaptive immunity has been considered. Here, we provide first evidence for a role of the key innate immune receptor, LPS receptor (CD14) in ...
Letiembre, Maryse, Engelhardt, B., Doering, Axinia, Wenlin Hao, Hao, W. L., Doering, A., Yang Liu, Fassbender, Klaus, Bernreuther, Christian, Walter, Silke, Klaus Fassbender, Axinia Doering, Maryse Letiembre, Markus Glatzel, Christian Bernreuther, Diem, Ricarda, Walter, S., Engelhardt, Britta, Liu, Yang, Liu, Y., Britta Engelhardt, Ricarda Diem, Silke Walter, Glatzel, Markus, Hao, Wenlin   +24 more
core   +3 more sources

Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]

PLoS ONE, 2013
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz, Estibaliz González-Fernández, Juan Carlos Chara Ventura, Alberto Pérez-Samartín, Leonid Tarassishin, Hiromitsu Negoro, Naman K Patel, Sylvia O Suadicani, Sunhee C Lee, Carlos Matute, Eliana Scemes   +10 more
doaj   +1 more source

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

Acta Neuropathologica, 2019
Neuroinflammation is the coordinated response of the central nervous system (CNS) to threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens and trauma. Activated astrocytes, in concert with other cellular elements of
R. Brambilla
semanticscholar   +1 more source

Silencing miR-150 Ameliorates Experimental Autoimmune Encephalomyelitis

Frontiers in Neuroscience, 2018
MiR-150 regulates maturation and differentiation of T cells but how it functions in multiple sclerosis (MS) is unclear. In miR-150 knockout (KO) mice, we examined the effect of miR-150 deletion on disease severity of experimental autoimmune ...
Zhaolan Hu, Yanhui Cui, Xiaoqing Qiao, Xinwen He, Fang Li, Cong Luo, Shuang Wang, Changqi Li, Ruping Dai   +8 more
doaj   +1 more source