Results 11 to 20 of about 6,369,773 (275)
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler +6 more
doaj +3 more sources
Experimental Autoimmune Encephalomyelitis [PDF]
, 1995 Experimental Autoimmune Encephalomyelitis (EAE) is the prototype for cell-mediated autoimmune disease in general, and is the best animal model of human CNS inflammatory demyelinating disease. It has three forms, which vary in clinical course and neuropathology: acute EAE, hyperacute EAE and chronic relapsing EAE.
Pender, Michael P.
core +5 more sources
Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis [PDF]
Frontiers in ImmunologyMacrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells can
Alexander Muselman +10 more
doaj +2 more sources
Peptide immunotherapy in experimental autoimmune encephalomyelitis
Biomedical Journal, 2015 We now have potent drugs available to treat the inflammatory component of multiple sclerosis (MS). However, not all patients respond, the drugs are not curative, and the associated risks to beneficial immune surveillance are considerable.
Stephen M Anderton
doaj +3 more sources
PLoS ONE, 2019 Antibodies, including antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1, have been shown to contribute to the pathogenesis of multiple sclerosis, thus it is important to assess their biological activity using animal models ...
Sangmin Lee +2 more
doaj +2 more sources
Experimental Autoimmune Encephalomyelitis in Mice [PDF]
Methods in molecular biology, 2016 Experimental autoimmune encephalitis (EAE), the animal model of multiple sclerosis (MS), has provided significant insight into the mechanisms that initiate and drive autoimmunity.
Rachael L. Terry +2 more
semanticscholar +3 more sources
A2 astrocyte polarization mediates ketogenic diet protection of blood–central nervous system barriers in experimental autoimmune encephalomyelitis [PDF]
Neural Regeneration ResearchDisruption of the blood–brain barrier and blood-spinal cord barrier is a fundamental pathological feature of multiple sclerosis progression. The ketogenic diet has a high therapeutic potential for patients with multiple sclerosis.
Qianye Zhang +5 more
doaj +2 more sources
Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]
PLoS ONE, 2013 Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris +7 more
doaj +4 more sources
Opposing T Cell Responses in Experimental Autoimmune Encephalomyelitis [PDF]
Nature, 2019 Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ T cells in the blood and central nervous system, similar to gluten-challenge ...
N. Saligrama +15 more
semanticscholar +2 more sources