Results 11 to 20 of about 40,848 (156)

In Vivo and In Vitro Evidence for an Interplay between the Glucocorticoid Receptor and the Vitamin D Receptor Signaling

Cells, 2023
Our previous work demonstrated that vitamin D (VitD) reduces experimental autoimmune encephalomyelitis (EAE) disease severity in wild-type (WT) but not in T cell-specific glucocorticoid (GC) receptor (GR)-deficient (GRlck) mice.
Maud Bagnoud, Jana Remlinger, Marine Massy, Dmitri Lodygin, Anke Salmen, Andrew Chan, Fred Lühder, Robert Hoepner   +7 more
doaj   +1 more source

Peptide immunotherapy in experimental autoimmune encephalomyelitis

Biomedical Journal, 2015
We now have potent drugs available to treat the inflammatory component of multiple sclerosis (MS). However, not all patients respond, the drugs are not curative, and the associated risks to beneficial immune surveillance are considerable.
Stephen M Anderton
doaj   +1 more source

Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.

PLoS ONE, 2019
Antibodies, including antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1, have been shown to contribute to the pathogenesis of multiple sclerosis, thus it is important to assess their biological activity using animal models ...
Sangmin Lee, Hannah E Salapa, Michael C Levin   +2 more
doaj   +1 more source

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

Journal of Neuroinflammation, 2017
Background Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenting cells.
Euan R. O. Allan, Rhiannon I. Campden, Benjamin W. Ewanchuk, Pankaj Tailor, Dale R. Balce, Neil T. McKenna, Catherine J. Greene, Amy L. Warren, Thomas Reinheckel, Robin M. Yates   +9 more
doaj   +1 more source

Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways

Journal of Ginseng Research, 2018
Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated.
Min Jung Lee, Byung Joon Chang, Seikwan Oh, Seung-Yeol Nah, Ik-Hyun Cho   +4 more
doaj   +1 more source

Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses

Frontiers in Immunology, 2020
Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang, Yan-Mei Huang, Xue-Zhi Hong, Xue-Zhi Hong, Jian Shen, Jian Shen, Li-Jun Geng, Li-Jun Geng, Yan-Hong Pan, Yan-Hong Pan, Wei Ling, Wei Ling, Hai-Lu Zhao, Hai-Lu Zhao, Hai-Lu Zhao   +14 more
doaj   +1 more source

Hormones in experimental autoimmune encephalomyelitis (EAE) animal models

Translational Neuroscience, 2021
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination.
Ghareghani Majid, Ghanbari Amir, Eid Ali, Shaito Abdullah, Mohamed Wael, Mondello Stefania, Zibara Kazem   +6 more
doaj   +1 more source

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

Journal of Neuroinflammation, 2012
Background Prions, composed of a misfolded protein designated PrPSc, are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomyelitis, prion-infected mice ...
Friedman-Levi Yael, Hoftberger Romana, Budka Herbert, Mayer-Sonnenfeld Tehila, Abramsky Oded, Ovadia Haim, Gabizon Ruth   +6 more
doaj   +1 more source

DCIR-mediated inhibitory regulation of TLR7-MyD88 axis prevents autoimmune neuroinflammation

iScience
Summary: Encephalitogenic T cells are responsible for developing autoimmune diseases in the central nervous system (CNS), but the pathogenesis of CNS autoimmune diseases remains incompletely understood.
Atsushi Fujioka, Kenji Shimizu, Saki Nakayama, Dai Ueno, Yuki Chiba, Ichiro Nakashima, Juichi Fujimori, Yuko Shirota, Yoichiro Iwakura, Yasushi Muraki, Akira Nakamura, Tomonori Kaifu   +11 more
doaj   +1 more source

Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II

Frontiers in Immunology, 2022
Tim-3, an immune checkpoint inhibitor, is widely expressed on the immune cells and contributes to immune tolerance. However, the mechanisms by which Tim-3 induces immune tolerance remain to be determined.
Lili Tang, Ge Li, Yang Zheng, Chunmei Hou, Yang Gao, Ying Hao, Zhenfang Gao, Rongliang Mo, Yuxiang Li, Beifen Shen, Renxi Wang, Zhiding Wang, Zhiding Wang, Gencheng Han   +13 more
doaj   +1 more source