Results 41 to 50 of about 6,369,773 (275)

In Vivo and In Vitro Evidence for an Interplay between the Glucocorticoid Receptor and the Vitamin D Receptor Signaling

Cells, 2023
Our previous work demonstrated that vitamin D (VitD) reduces experimental autoimmune encephalomyelitis (EAE) disease severity in wild-type (WT) but not in T cell-specific glucocorticoid (GC) receptor (GR)-deficient (GRlck) mice.
Maud Bagnoud, Jana Remlinger, Marine Massy, Dmitri Lodygin, Anke Salmen, Andrew Chan, Fred Lühder, Robert Hoepner   +7 more
doaj   +1 more source

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

Journal of Neuroinflammation, 2017
Background Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenting cells.
Euan R. O. Allan, Rhiannon I. Campden, Benjamin W. Ewanchuk, Pankaj Tailor, Dale R. Balce, Neil T. McKenna, Catherine J. Greene, Amy L. Warren, Thomas Reinheckel, Robin M. Yates   +9 more
doaj   +1 more source

Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis

Arthritis & Rheumatology, 2019
Glutaminase 1 (Gls1) is the first enzyme in glutaminolysis. The selective Gls1 inhibitor bis‐2‐(5‐phenylacetamido‐1,3,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES) suppresses Th17 development and ameliorates experimental autoimmune encephalomyelitis (EAE). The
M. Kono, N. Yoshida, K. Maeda, A. Suárez-Fueyo, V. Kyttaris, G. Tsokos   +5 more
semanticscholar   +1 more source

Experimental Autoimmune Encephalomyelitis (EAE) [PDF]

Current Protocols in Neuroscience, 2001
AbstractThe procedures described in this unit utilize murine models exclusively since murine EAE often results in a relapsing/remitting disease, similar to the early phase of most MS patients. EAE in the Lewis rat is a monophasic illness in which animals experience a single episode of paralysis from which most recover completely. This unit presents two
openaire   +2 more sources

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Thézé, Benoit, Dollé, Frédéric, Brulon, Vincent, Fontyn, Yoann, Abourbeh, Galith, Dubois, Albertine, Tavitian, Bertrand, Boisgard, Raphael, Maroy, Renaud   +8 more
core   +1 more source

Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways

Journal of Ginseng Research, 2018
Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated.
Min Jung Lee, Byung Joon Chang, Seikwan Oh, Seung-Yeol Nah, Ik-Hyun Cho   +4 more
doaj   +1 more source

Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses

Frontiers in Immunology, 2020
Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang, Yan-Mei Huang, Xue-Zhi Hong, Xue-Zhi Hong, Jian Shen, Jian Shen, Li-Jun Geng, Li-Jun Geng, Yan-Hong Pan, Yan-Hong Pan, Wei Ling, Wei Ling, Hai-Lu Zhao, Hai-Lu Zhao, Hai-Lu Zhao   +14 more
doaj   +1 more source

Reduced expression of the ferroptosis inhibitor GPx4 in multiple sclerosis and experimental autoimmune encephalomyelitis

Journal of Neurochemistry, 2018
Glutathione peroxidase 4 (GPx4) is the only enzyme capable of reducing toxic lipid hydroperoxides in biological membranes to the corresponding alcohols using glutathione as the electron donor.
Che‐lin Hu, Mara Nydes, Kara L. Shanley, Itzy E. Morales Pantoja, T. Howard, O. Bizzozero   +5 more
semanticscholar   +1 more source

Hormones in experimental autoimmune encephalomyelitis (EAE) animal models

Translational Neuroscience, 2021
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination.
Ghareghani Majid, Ghanbari Amir, Eid Ali, Shaito Abdullah, Mohamed Wael, Mondello Stefania, Zibara Kazem   +6 more
doaj   +1 more source

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

Experimental Neurology, 2018
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by progressive neuronal demyelination and degeneration.
Jillian C. Nissen, K. Thompson, B. West, S. Tsirka   +3 more
semanticscholar   +1 more source