Results 41 to 50 of about 49,810 (235)

The Innate Immune Receptor CD14 Mediates Lymphocyte Migration in EAE

Cellular Physiology and Biochemistry, 2015
Background: Multiple sclerosis is the most common autoimmune disease of the central nervous system in young adults and histopathologically characterized by inflammation, demyelination and gliosis.
Ramona Halmer, Laura Davies, Yang Liu, Klaus Fassbender, Silke Walter   +4 more
doaj   +1 more source

ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2020
Background ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation.
Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang, Yuwu Zhao   +9 more
doaj   +1 more source

Computational Modelling of Treg Networks in Experimental Autoimmune Encephalomyelitis [PDF]

, 2011
Recent experiments have demonstrated the value of rigorously validated simulation in furthering our understanding of immunology. We seek to expand on a body of existing work at York in which we simulate the mouse disease, Experimental Autoimmune ...
Greaves, Richard
core  

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Mechanical hypernociception in experimental autoimmune encephalomyelitis [PDF]

Arquivos de Neuro-Psiquiatria, 2009
BACKGROUND: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. OBJECTIVE: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice.
Rodrigues, David Henrique, Sachs, Daniela, Teixeira, Antonio Lucio   +2 more
openaire   +4 more sources

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses. [PDF]

, 2021
BACKGROUND Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS).
Hélie, Pauline, Docagne, Fabian, Guérit, Sylvaine, Bardou, Isabelle, Vivien, Denis, Miralles, Antonio J, Vila-Del Sol, Virginia, Le Mauff, Brigitte, Camacho-Toledano, Celia, Lebas, Héloïse, Toutirais, Olivier, Seillier, Célia, Clemente, Diego, Ortega, Maria Cristina, Lesec, Léonie   +14 more
core   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Studies in the Modulation of Experimental Autoimmune Encephalomyelitis [PDF]

Journal of Neuroimmune Pharmacology, 2010
Experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, can be induced through inoculation with several different central nervous system (CNS) proteins or peptides. Modulation of EAE, resulting in either protection from EAE or enhancement of EAE, can also be accomplished through either vaccination or DNA ...
Jane E, Libbey, Ikuo, Tsunoda, Robert S, Fujinami   +2 more
openaire   +2 more sources