Results 51 to 60 of about 6,369,773 (275)

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

Cannabinoids for the control of experimental multiple sclerosis [PDF]

, 2010
PhDThere have been numerous studies reporting that cannabinoids, both exogenous and endogenous, have a potential beneficial function during incidences of neurological damage.
Pryce, Gareth
core   +2 more sources

Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives

Mediators of Inflammation, 2018
The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS).
Feng-Na Chu, Ming-Chao Shi, Yue Lang, Donghui Shen, T. Jin, Jie Zhu, Li Cui   +6 more
semanticscholar   +1 more source

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

Journal of Neuroinflammation, 2012
Background Prions, composed of a misfolded protein designated PrPSc, are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomyelitis, prion-infected mice ...
Friedman-Levi Yael, Hoftberger Romana, Budka Herbert, Mayer-Sonnenfeld Tehila, Abramsky Oded, Ovadia Haim, Gabizon Ruth   +6 more
doaj   +1 more source

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

Journal of Experimental Medicine, 2019
In this study, Li et al. demonstrate that gasdermin D in peripheral myeloid cells promotes the activation and differentiation of T cell in the secondary lymphoid organs, thus driving T cell–mediated neuroinflammation and demyelination in the CNS of EAE ...
Sheng Li, Yu-Qing Wu, Dong-Xue Yang, Chunyan Wu, Chun-Mei Ma, Xue Liu, P. Moynagh, Bing-Wei Wang, Gang Hu, Shuo Yang   +9 more
semanticscholar   +1 more source

Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II

Frontiers in Immunology, 2022
Tim-3, an immune checkpoint inhibitor, is widely expressed on the immune cells and contributes to immune tolerance. However, the mechanisms by which Tim-3 induces immune tolerance remain to be determined.
Lili Tang, Ge Li, Yang Zheng, Chunmei Hou, Yang Gao, Ying Hao, Zhenfang Gao, Rongliang Mo, Yuxiang Li, Beifen Shen, Renxi Wang, Zhiding Wang, Zhiding Wang, Gencheng Han   +13 more
doaj   +1 more source

Opposing functions of microglial and macrophagic TNFR2 in the pathogenesis of experimental autoimmune encephalomyelitis

Cell Reports, 2017
Summary In multiple sclerosis (MS), soluble tumor necrosis factor (TNF) is detrimental via activation of TNF receptor 1 (TNFR1), whereas transmembrane TNF is beneficial primarily by activating TNF receptor 2 (TNFR2). Here we investigate the role of TNFR2
Han Gao, M. Danzi, Claire S. Choi, M. Taherian, Camilla Dalby-Hansen, D. Ellman, Pernille M. Madsen, J. Bixby, V. Lemmon, K. Lambertsen, R. Brambilla   +10 more
semanticscholar   +1 more source

DCIR-mediated inhibitory regulation of TLR7-MyD88 axis prevents autoimmune neuroinflammation

iScience
Summary: Encephalitogenic T cells are responsible for developing autoimmune diseases in the central nervous system (CNS), but the pathogenesis of CNS autoimmune diseases remains incompletely understood.
Atsushi Fujioka, Kenji Shimizu, Saki Nakayama, Dai Ueno, Yuki Chiba, Ichiro Nakashima, Juichi Fujimori, Yuko Shirota, Yoichiro Iwakura, Yasushi Muraki, Akira Nakamura, Tomonori Kaifu   +11 more
doaj   +1 more source

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Frontiers in Immunology, 2017
The CD40–CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune responses and has therefore an essential role in the development of inflammatory diseases, including multiple sclerosis (MS).
S. Aarts, T. Seijkens, Koos J. F. van Dorst, C. Dijkstra, G. Kooij, E. Lutgens   +5 more
semanticscholar   +1 more source