Results 71 to 80 of about 6,369,773 (275)

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

Cell Death and Differentiation, 2016
Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease, characterized by chronic inflammatory demyelination in the nervous tissue and subsequent neurological dysfunction.
Q. Yang, C. Zheng, J. Cao, G. Cao, P. Shou, L. Lin, T. Velletri, M. Jiang, Q. Chen, Y. Han, F. Li, Y. Wang, W. Cao, Y. Shi   +13 more
semanticscholar   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Utility of the APE2 Score as a Diagnostic Tool for Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort, including antibody‐negative AE.
Bijoya Basu, Sophia F. Damman, Samhitha M. Rai, Hesham Abboud   +3 more
wiley   +1 more source

Dinámica de Linfocitos T en Autoinmunidad. Línea de investigación: Neurociencias clínicas y experimentales [PDF]

, 2013
[esp] La Esclerosis Multiple (EM) se ha considerado una enfermedad autoinmune mediada por linfocitos T con un comportamiento oscilatorio prototípico, caracterizado por la presencia de brotes clínicos. Por tanto, comprender la dinámica de las células del
Martínez Pasamar, Sara
core   +3 more sources

Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis [PDF]

, 2018
BACKGROUND: Muscle carnosine is related to contractile function (Ca++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS ...
Eijnde, Bert O., Missinne, Maarten, Van Noten, Pieter, Inez Wens, Blancquaert, Laura, Derave, Wim, Charly Keytsman, Laura Blancquaert, Pieter Van Noten, Bert O. Eijnde, Missine, Maarten, Keytsman, Charly, Maarten Missine, Frank Vandenabeele, Wim Derave, Eijnde, Bert O, Vandenabeele, Frank, Wens, Inez   +17 more
core   +1 more source

Modulation by Anisakis simplex antigen of inflammatory response generated in experimental autoimmune encephalomyelitis [PDF]

, 2021
The impact of immunization with Anisakis simplex larval antigen on the occurrence and progression of experimental autoimmune encephalomyelitis (EAE) induced in mice was studied.
Cuéllar Del Hoyo, María Del Carmen, Rodero Martínez, Marta, Carmen Cuéllar, Marta Rodero   +3 more
core   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

Nature Immunology, 2016
Interleukin 1β (IL-1β) is critical for the in vivo survival, expansion and effector function of IL-17–producing helper T (TH17) cells during autoimmune responses, including experimental autoimmune encephalomyelitis (EAE). However, the spatiotemporal role
B. Martin, Chen-Hui Wang, Cun-Jin Zhang, Zi-Zhen Kang, M. F. Gulen, J. Zepp, Jun-Jie Zhao, Guanglin Bian, Jeong-su Do, Booki Min, P. Pavicic, Caroline El-Sanadi, P. Fox, Akitsu Aoi, Y. Iwakura, A. Sarkar, M. Wewers, W. Kaiser, E. Mocarski, M. Rothenberg, A. Hise, G. Dubyak, R. Ransohoff, Xiao-Xia Li   +23 more
semanticscholar   +1 more source

Studies in the Modulation of Experimental Autoimmune Encephalomyelitis [PDF]

Journal of Neuroimmune Pharmacology, 2010
Experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, can be induced through inoculation with several different central nervous system (CNS) proteins or peptides. Modulation of EAE, resulting in either protection from EAE or enhancement of EAE, can also be accomplished through either vaccination or DNA ...
Jane E, Libbey, Ikuo, Tsunoda, Robert S, Fujinami   +2 more
openaire   +2 more sources

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source