Generation of ventralized human thalamic organoids with thalamic reticular nucleus [PDF]
Cell Stem Cell, 2023 Human brain organoids provide unique platforms for modeling several aspects of human brain development and pathology. However, current brain organoid systems mostly lack the resolution to recapitulate the development of finer brain structures with subregional identity, including functionally distinct nuclei in the thalamus. Here, we report a method for
Bilal Cakir +2 more
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Involvement of the thalamic reticular nucleus in prepulse inhibition of acoustic startle [PDF]
Translational Psychiatry, 2021 Thalamic reticular nucleus (TRN) is a group of inhibitory neurons surrounding the thalamus. Due to its important role in sensory information processing, TRN is considered as the target nucleus for the pathophysiological investigation of schizophrenia and
Qiang-long You +7 more
doaj +2 more sources
Characterization of the neural circuitry of the auditory thalamic reticular nucleus and its potential role in salicylate-induced tinnitus [PDF]
Frontiers in NeuroscienceIntroductionSubjective tinnitus, the perception of sound without an external acoustic source, is often subsequent to noise-induced hearing loss or ototoxic medications.
Qian Dai +3 more
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NR2C in the thalamic reticular nucleus; effects of the NR2C knockout. [PDF]
PLoS ONE, 2012 NMDAR antagonists can evoke delta frequency bursting in the nucleus reticularis of the thalamus (nRT). The mechanism of this oscillation was determined; antagonist blocks an NR2C-like conductance that has low Mg block at resting potential and thus can ...
Yuchun Zhang +4 more
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Layer 5 of cortex innervates the thalamic reticular nucleus in mice [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Vandana Sampathkumar, S Murray Sherman
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Distinct subnetworks of the thalamic reticular nucleus. [PDF]
Nature, 2020 The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates thalamocortical interactions that are critical for sensory processing, attention and cognition1-5. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders6-9.
Li Y +29 more
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Role of the Thalamic Reticular Nucleus in Social Memory. [PDF]
Neurosci BullLiu X, Zhu J, Zheng J, Xu H.
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Corticothalamic gating of population auditory thalamocortical transmission in mouse
eLife, 2021 The mechanisms that govern thalamocortical transmission are poorly understood. Recent data have shown that sensory stimuli elicit activity in ensembles of cortical neurons that recapitulate stereotyped spontaneous activity patterns.
Baher A Ibrahim +5 more
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Knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice
Nature Communications, 2022 Uygun et al. show that deletion of GABAA receptors from the thalamic reticular nucleus using CRISPR gene editing in mice boosts the delta waves, indicating a role for GABAA receptors on thalamic reticular nucleus neurons in NREM sleep delta oscillations.
David S. Uygun +8 more
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The Thalamic Reticular Nucleus and Schizophrenia [PDF]
Schizophrenia Bulletin, 2010 The thalamic reticular nucleus (TRN) is a shell-shaped gamma amino butyric acid (GABA)ergic nucleus, which is uniquely placed between the thalamus and the cortex, because it receives excitatory afferents from both cortical and thalamic neurons and sends inhibitory projections to all nuclei of the dorsal thalamus.A review of the evidence suggesting that
Fabio, Ferrarelli, Giulio, Tononi
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