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The Next Frontier in Parkinson's Disease Treatment: A Narrative Review of Innovative Neurosurgical and Gene Therapy Approaches [PDF]

Health Science Reports
Background and Aims Parkinson's disease (PD) is a progressive neurological condition that consists of both motor and non‐motor symptoms that considerably deteriorate the quality of life.
Muhammad Shaheer Bin Faheem, Muhammad Haroon‐Ul‐Rasheed, Rohma Aftab, Qasra Faheem, Faheem Feroze, Hafiza Qurat Ul Ain, Sumaya Samadi   +6 more
doaj   +2 more sources

Quantitative and qualitative tremor evaluation after MR-guided focused ultrasound thalamotomy [PDF]

Frontiers in Neurology
IntroductionTremor syndromes are common neurological disorders, usually distinguished by clinical examination. Ordinal rating scales are widely used to rate tremor severity but are limited by subjective observation, interrater reliability, ceiling ...
Veronika Purrer, Veronika Purrer, Tara Chand, Tara Chand, Tara Chand, Emily Pohl, Hannah Weiland, Valeri Borger, Carsten Schmeel, Henning Boecker, Henning Boecker, Ullrich Wüllner, Ullrich Wüllner   +12 more
doaj   +2 more sources

Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor [PDF]

Brain, 2018
Alexandre Boutet, Jurgen Germann, Nir Lipsman   +2 more
exaly   +2 more sources

Technical Comparison of Treatment Efficiency of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy and Pallidotomy in Skull Density Ratio-Matched Patient Cohorts

Frontiers in Neurology, 2022
ObjectiveMR-guided focused ultrasound (MRgFUS) is increasingly being used to treat patients with essential tremor (ET) and Parkinson's disease (PD) with thalamotomy and pallidotomy, respectively.
Abdul-Kareem Ahmed, Sijia Guo, Nathaniel Kelm, Ryan Clanton, Elias R. Melhem, Rao P. Gullapalli, Alexander Ksendzovsky, Howard M. Eisenberg, Timothy R. Miller, Timothy R. Miller, Dheeraj Gandhi, Dheeraj Gandhi   +11 more
doaj   +1 more source

Lateralized Effects of Unilateral Thalamotomy and Thalamic Stimulation in Patients with Essential Tremor [PDF]

Journal of Movement Disorders, 2011
Background and Purpose Stereotactic thalamotomy has been an effective surgical procedure in the treatment of medically refractory essential tremor (ET), however, little is known about the bilateral effects of unilateral ventralis intermedius (Vim ...
Mi J. Kim, Sang R. Jeon, Sung R. Kim, Myoung C. Lee, Sun J. Chung   +4 more
doaj   +1 more source

Stroke Mimicking Thalamotomy in Primary Familial Brain Calcification. [PDF]

Mov Disord Clin Pract
Kungshamn J, Ottela E, Likitalo O, Brück A, Joutsa J.   +4 more
europepmc   +3 more sources

Case Report: Long-Term Suppression of Paroxysmal Kinesigenic Dyskinesia After Bilateral Thalamotomy

Frontiers in Neurology, 2021
Background: Paroxysmal kinesigenic dyskinesia (PKD) is a movement disorder characterized by transient dyskinetic movements, including dystonia, chorea, or both, triggered by sudden voluntary movements.
Masato Murakami, Shiro Horisawa, Kenko Azuma, Hiroyuki Akagawa, Taku Nonaka, Takakazu Kawamata, Takaomi Taira   +6 more
doaj   +1 more source

Comprehensive Evaluation of Factors Affecting Tremor Relapse after MRgFUS Thalamotomy: A Case-Control Study

Brain Sciences, 2021
Objective: To identify possible relevant factors contributing to tremor relapse after MRgFUS thalamotomy in patients with essential tremor (ET) and Parkinson’s disease (PD).
Federico Bruno, Alessia Catalucci, Francesco Arrigoni, Alessio Gagliardi, Elena Campanozzi, Antonella Corridore, Emanuele Tommasino, Valeria Pagliei, Leonardo Pertici, Pierpaolo Palumbo, Patrizia Sucapane, Davide Cerone, Francesca Pistoia, Ernesto Di Cesare, Antonio Barile, Alessandro Ricci, Carmine Marini, Alessandra Splendiani, Carlo Masciocchi   +18 more
doaj   +1 more source

Treatment strategy in stereotactic radiosurgery for trigeminal neuralgia, essential tremor, and coexisting intracranial tumors: The impact of biologically effective dose on clinical outcome. [PDF]

J Appl Clin Med Phys
Abstract Background Gamma Knife radiosurgery (GKRS) is a well‐established treatment for trigeminal neuralgia (TN) and essential tremor (ET). In patients with coexisting intracranial tumors, radiosurgery can potentially address functional and oncologic targets in a single or staged session.
Sinha S, Goulenko V, Madhugiri VS, Prasad S, Almeida ND, Shekher R, Podgorsak MB, Plunkett RJ, Prasad D.   +8 more
europepmc   +2 more sources

Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy

Frontiers in Aging Neuroscience, 2022
Essential tremor (ET) is the most common movement disorder. Its pathophysiology is only partially understood. Here, we leveraged graph theoretical analysis on structural covariance patterns quantified from morphometric estimates for cortical thickness ...
Thomas A. W. Bolton, Thomas A. W. Bolton, Dimitri Van De Ville, Dimitri Van De Ville, Jean Régis, Tatiana Witjas, Nadine Girard, Marc Levivier, Marc Levivier, Constantin Tuleasca, Constantin Tuleasca, Constantin Tuleasca   +11 more
doaj   +1 more source