Results 101 to 110 of about 255,451 (370)
Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease
Advanced Science, EarlyView.This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang +10 more
wiley +1 more source
The Aggregator Model of Spatial Cognition [PDF]
arXiv, 2020 Tracking the positions of objects in local space is a core function of animal brains. We do not yet understand how it is done with limited neural resources. The challenges of spatial cognition are discussed under the criteria: (a) scaling of computational costs; (b) feature binding; (c) precise calculation of spatial displacements; (d) fast learning of
arxiv
Vascular Syndromes of the Thalamus [PDF]
Stroke, 2003 Background— This article reviews the anatomy, connections, and functions of the thalamic nuclei, their vascular supply, and the clinical syndromes that result from thalamic infarction. Summary of Review— Thalamic nuclei are ...
openaire +2 more sources
Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model
Advanced Science, EarlyView.Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis +7 more
wiley +1 more source
eLife, 2016 Adaptive decision-making uses information gained when exploring alternative options to decide whether to update the current choice strategy. Magnocellular mediodorsal thalamus (MDmc) supports adaptive decision-making, but its causal contribution is not ...
Subhojit Chakraborty +3 more
doaj +1 more source
Advanced Science, EarlyView.The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge +16 more
wiley +1 more source
A cortico-subcortical loop for motor control via the pontine reticular formation
Cell ReportsSummary: Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem.
Emília Bősz +5 more
doaj
Thalamic reticular nucleus induces fast and local modulation of arousal state
eLife, 2015 During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence.
Laura D Lewis +6 more
doaj +1 more source
Advanced Science, EarlyView.How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu +13 more
wiley +1 more source
Medial thalamic stroke and its impact on familiarity and recollection
eLife, 2017 Models of recognition memory have postulated that the mammillo-thalamic tract (MTT)/anterior thalamic nucleus (AN) complex would be critical for recollection while the Mediodorsal nucleus (MD) of the thalamus would support familiarity and indirectly also
Lola Danet +8 more
doaj +1 more source