Results 181 to 190 of about 181,456 (327)

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation

Glia, Volume 74, Issue 1, January 2026.
Astrocytic ATRX loss causes non‐cell‐autonomous neuronal hyperexcitability. Inducing ATRX deficiency in astrocytes causes selective long‐term memory deficits. Dynamic transcriptomic changes reveal metabolic and synaptic pathway dysregulation. ABSTRACT Astrocytes are increasingly recognized as active regulators of synaptic transmission and memory, yet ...
Miguel A. Pena‐Ortiz, Julia K. Sunstrum, Alireza Ghahramani, Haley McConkey, Vanessa Dumeaux, Wataru Inoue, Nathalie G. Bérubé   +6 more
wiley   +1 more source

MeMAGEN: A Phase IIa/IIb open‐label trial of memantine testing safety and tolerability in sickle cell patients

HemaSphere, Volume 10, Issue 1, January 2026.
ABSTRACT Administration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD). The objectives of the 1‐year dose‐escalation Phase IIa/IIb Memantine trial (MeMAGEN – NCT 03247218) with 17 SCD patients who were under stable ...
Ariel Koren, Carina Levin, Leonid Livshits, Fabio Valeri, Sari Peretz, Sivan Raz, Anna Yu Bogdanova, Max Gassmann   +7 more
wiley   +1 more source

Folate supplementation in transfusion-dependent thalassemia: Do we really need such high doses?

, 2016
Gaurav Tripathi, Manas Kalra, Amita Mahajan   +2 more
openalex   +1 more source

Ineffective Erythropoiesis Markers in β-Thalassemia: A Systematic Review. [PDF]

J Clin Med
Prahasanti K, Ashariati A, Herawati L, Romadhon PZ, Mahdi BA, Dzakiyah AZ, Cahyono MBA, Yusoff NM.   +7 more
europepmc   +1 more source

Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic red blood cell (RBC) transfusion sustains patients with diverse hematologic disorders, but repeated transfusion leads to iron overload and alloimmunization. Reducing transfusion burden requires identifying donor units that circulate more effectively after storage, yet determinants of this variability remain incompletely defined.
James C. Zimring, Ariel M. Hay, Monika Dzieciatkowska, Daniel Stephenson, Zachary B. Haiman, Steven Kleinman, Philip J. Norris, Michael P. Busch, Nareg Roubinian, Elisa Fermo, Paola Bianchi, Gregory R. Keele, Grier P. Page, Angelo D'Alessandro   +13 more
wiley   +1 more source

Pregnancy Outcomes in Women With Thalassemia Trait: A Multicenter Cohort Study. [PDF]

Anemia
Chelysheva D, Syed A, Ruby H, Homeniuk A, Atrash A, Moussally FA.   +5 more
europepmc   +1 more source

Endocrine complications in transfusion-dependent β-thalassemia – A single center experience


Pediatric Hematology Oncology Journal
Binita Poudel, Ratna Sharma, Pranoti Kini, Arpita Gupta, Ruchi Parikh, Shruti Mondkar, Mugdha Todkar, Jatan Jagruk, Karishma Agrawal, Bhawana Gautam, Mamta Manglani   +10 more
doaj   +1 more source

Profiling structural variations of the α-globin gene cluster by the single molecule real-time sequencing: remarkable diversity of the spectrum with rare and novel variants identified in a large Chinese cohort. [PDF]

Hum Genet
Wei D, Cheng Z, Wei W, Gui C, Liu J, Chen H, Ma Y, Peng X, Yu D, Huang Y, Lai Y, Gui B.   +11 more
europepmc   +1 more source

Endocrine Function in Thalassemia Major [PDF]

, 1968
Braden Kuo, Edward C. Zaino, Martin S. Roginsky   +2 more
openalex   +1 more source

TNFAIP3 Gene Polymorphisms and the Risk of Thrombocytopenia: A Cross‐Sectional Study in Iranian Population

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Thrombocytopenia, particularly immune thrombocytopenic purpura, is a prevalent hematological disorder characterized by low platelet counts, leading to increased bleeding risks. Genetic factors, including single nucleotide polymorphisms, are implicated in its pathogenesis.
Sorour Alizadeh Saadooni, Zeinab Eftekhar, Mohammad Ali Jalali Far, Najmaldin Saki, Gholam Abbas Kydani, Hossein Karimpourian, Ali Aminasnafi   +6 more
wiley   +1 more source