Results 181 to 190 of about 140,652 (287)

A Multi‐Task Learning Approach for Identifying Prognostic Variables Across Multiple Historical Clinical Trials

Statistics in Medicine, Volume 45, Issue 23-24, October 2026.
ABSTRACT In clinical trials, it is critical to incorporate prognostic variables to improve precision for estimating treatment effects. Per FDA guidance, these prognostic variables need to be prospectively specified in the statistical analysis plan. Therefore, there is a great need to effectively identify prognostic variables from historical studies ...
Xueying Liu, Huijing Jiang, Jennie Zhang, Xinwei Deng   +3 more
wiley   +1 more source

Genotypic distribution and molecular spectrum of rare and novel thalassemia variants in Ganzhou, southern China. [PDF]

Front Mol Biosci
Huang J, Huang X, Xie X, Xin X.
europepmc   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, Volume 209, Issue 4, Page 1469-1481, October 2026.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Nanoplate Digital PCR for Identification of α⁰-Thalassemia (SEA Deletion): Carrier Screening and Possible Application to Prenatal Diagnosis. [PDF]

Int J Mol Sci
Pattrakorn A, Yamsri S, Chaibunruang A, Pansuwan A, Tepakhan W, Singha K, Fucharoen S, Srivorakun H.   +7 more
europepmc   +1 more source

Combination Therapy With Proton Pump Inhibitors and Iron Chelators in Hereditary Anaemias With Secondary Iron Overload

eJHaem, Volume 7, Issue 5, October 2026.
Thomas Doeven, Annelies van Vuren, Andreas Glenthøj, Jean Louis Kerkhoffs, Saskia E. M. Schols, Anita Rijneveld, Erfan Nur, Dore Peereboom, Paco Welsing, Roger Schutgens, Bart J. Biemond, Eduard J. van Beers   +11 more
wiley   +1 more source

Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia

British Journal of Haematology, Volume 209, Issue 4, Page 1856-1865, October 2026.
Summary Cerebral macrovasculopathy (CV) is a major complication in children with sickle cell anaemia (SCA) and usually requires a long‐term transfusion programme (TP) to prevent stroke. This study aimed to identify factors predicting reversal of CV on TP in a single‐centre newborn cohort. Among 375 patients, 50 presented CV and received TP.
Julie Sommet, Priscilla Boizeau, Zinedine Haouari, Berengère Koehl, Monique Elmaleh, Emmanuelle Lesprit, Florence Missud, Ghislaine Ithier, Laurent Holvoet, Valentine Brousse, Christophe Delclaux, André Denjean, Suzanne Verlhac, Corinne Alberti, André Baruchel, Nathalie Couque, Malika Benkerrou   +16 more
wiley   +1 more source

Development and Internal Validation of a Machine Learning-Based Model for Thalassemia Identification Using Complete Blood Count Parameters. [PDF]

Diagnostics (Basel)
Yin P, Tan J, Hong H.
europepmc   +1 more source

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

British Journal of Haematology, Volume 209, Issue 4, Page 1845-1855, October 2026.
Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters ...
Matthias Bleeke, Arne Simon, Beate Winkler, Sabine Heine, Anna Eichinger, Ulrich von Both, Meinolf Siepermann, Sonya El Amouri, Arndt Borkhardt, Yvonne Pritschow, Wolfgang Novak, Michael Dworzak, Sarah Goretzki, Clara Held, Karin Beutel, Franziska Gams, Henriette Rudolph, Leila Koscher, Piet E. Beusker, Eckard Hamelmann, Stefan Weichert, Svenja Häuser, Maximilian Mauritz, Malik Aydin, Verena Wiegering, Regine Grosse, Rainer Misgeld, Martina Stiefel, Nicole Töpfner, Uta Falke, Lara Imhof, Laura Tagliaferri, Daniel Ebrahimi‐Fakhari, Andreas Groll, Marion Appel, Nora Naumann‐Bartsch, Michaela Nathrath, Olaf Beck, Solvej Heidtmann, Philipp Tischer, Ulf Schulze‐Sturm, Urs Mücke, Holger Cario   +42 more
wiley   +1 more source

Hemoglobinopathies and Thalassemia in Northeast India: A Scoping Review of Disease Burden, Mutation Spectrum, and Gaps in Molecular Genetic Evidence. [PDF]

Cureus
Pathak MS, Chisty SJS, Pathak P, Borah MS, Mazumder T.   +4 more
europepmc   +1 more source

Multicentric Asynchronous Endocrine Mucin‐Producing Sweat Gland Carcinoma and Mucinous Carcinoma of the Skin

Journal of Cutaneous Pathology, Volume 53, Issue 10, Page 901-906, October 2026.
ABSTRACT Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is an adnexal neoplasm which typically occurs on periorbital skin and demonstrates overlapping histopathologic features with primary mucinous carcinoma of the skin (MCS). Herein, we report a patient who developed five distinct lesions of EMPSGC and MCS over an eight‐year period, some of ...
Ikuko Hirai, Joseph F. Sobanko, Tara C. Mitchell, Jacquelyn Roth, Rosalie Elenitsas, Emily Y. Chu   +5 more
wiley   +1 more source