Results 181 to 190 of about 114,325 (234)
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Hematology, 2004
Abstract New developments in the epidemiology, treatment and prognosis of thalassemia have dramatically altered the approach to the care of affected patients, and these developments are likely to have an even greater impact in the next few years.
Alan R, Cohen +4 more
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Abstract New developments in the epidemiology, treatment and prognosis of thalassemia have dramatically altered the approach to the care of affected patients, and these developments are likely to have an even greater impact in the next few years.
Alan R, Cohen +4 more
openaire +2 more sources
Pediatric Clinics of North America, 2013
The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation.
Alissa, Martin, Alexis A, Thompson
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The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation.
Alissa, Martin, Alexis A, Thompson
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Hemoglobin, 2022
Management and control of hemoglobinopathies are a challenge in India where 67.0% of people reside in rural regions. The GDP spent on health is one of the lowest (1.3%) resulting in high out-of-pocket expenses. The β-thalassemias are prevalent with an estimated 7500-12000 new births each year. Hb S (HBB: c.20A>T) and Hb E (HBB: c.79G>A) are also common
Roshan B, Colah, Tulika, Seth
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Management and control of hemoglobinopathies are a challenge in India where 67.0% of people reside in rural regions. The GDP spent on health is one of the lowest (1.3%) resulting in high out-of-pocket expenses. The β-thalassemias are prevalent with an estimated 7500-12000 new births each year. Hb S (HBB: c.20A>T) and Hb E (HBB: c.79G>A) are also common
Roshan B, Colah, Tulika, Seth
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Hemoglobin, 2022
Thailand has a population of 66.2 million with 30.0-40.0% of them carrying thalassemia genes. Interaction of these thalassemia genes lead to more than 60 genotypes with a wide spectrum of clinical severity from asymptomatic to lethal. Estimation based on gene frequencies and number of babies born each year, there will be about 1.2% babies born with ...
Kittiphong Paiboonsukwong +3 more
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Thailand has a population of 66.2 million with 30.0-40.0% of them carrying thalassemia genes. Interaction of these thalassemia genes lead to more than 60 genotypes with a wide spectrum of clinical severity from asymptomatic to lethal. Estimation based on gene frequencies and number of babies born each year, there will be about 1.2% babies born with ...
Kittiphong Paiboonsukwong +3 more
openaire +2 more sources
American Journal of Hematology, 1977
AbstractThe current concepts of α‐thalassemia including incidence, genetics, clinical spectrum and diagnosis are reviewed. Speculation concerning clinical application of the molecular biology of α‐thalassemia is also presented.
J G, Adams, M H, Steinberg
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AbstractThe current concepts of α‐thalassemia including incidence, genetics, clinical spectrum and diagnosis are reviewed. Speculation concerning clinical application of the molecular biology of α‐thalassemia is also presented.
J G, Adams, M H, Steinberg
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The Journal of Bone & Joint Surgery, 1976
Fractures occur frequently in patients with homozygous beta-thalassemia. A study was made of the fractures noted in a group of patients who were followed at the Thalassemia Clinic at The New York Hospital-Cornell Medical Center. Results indicate that these patients often sustain fractures which are multiple and which frequently heal with resultant ...
D M, Dines, V C, Canale, W D, Arnold
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Fractures occur frequently in patients with homozygous beta-thalassemia. A study was made of the fractures noted in a group of patients who were followed at the Thalassemia Clinic at The New York Hospital-Cornell Medical Center. Results indicate that these patients often sustain fractures which are multiple and which frequently heal with resultant ...
D M, Dines, V C, Canale, W D, Arnold
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Human Fertility, 2016
Beta-thalassemia (BTM) major is the most common haemoglobin disorder in the world, with high prevalence in people of Mediterranean, Arab or Asian origin. It has been estimated that about 1.5% of the global population (80-90 million people) are carriers of BTM.
Castaldi, Maria Antonietta +1 more
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Beta-thalassemia (BTM) major is the most common haemoglobin disorder in the world, with high prevalence in people of Mediterranean, Arab or Asian origin. It has been estimated that about 1.5% of the global population (80-90 million people) are carriers of BTM.
Castaldi, Maria Antonietta +1 more
openaire +4 more sources
Pediatrics In Review, 1992
Many advances in the understanding and management of the thalassmia syndromes have been made during the past several years. Our knowledge of normal globin gene function and of the consequences of specific mutations has been advanced by identification of the genetic defects causing thalassemia.
P J, Giardina, M W, Hilgartner
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Many advances in the understanding and management of the thalassmia syndromes have been made during the past several years. Our knowledge of normal globin gene function and of the consequences of specific mutations has been advanced by identification of the genetic defects causing thalassemia.
P J, Giardina, M W, Hilgartner
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Hematology/Oncology Clinics of North America, 2023
Edward J, Benz, Vijay G, Sankaran
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Edward J, Benz, Vijay G, Sankaran
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Pathophysiology of thalassemia
Current Opinion in Hematology, 2002Despite discoveries concerning the molecular abnormalities that led to the thalassemic syndromes, it still is not known how accumulation of excess unmatched alpha-globin in beta thalassemia and beta-globin in alpha thalassemia leads to red blood cell hemolysis in the peripheral blood, and in the beta thalassemias particularly, premature destruction of ...
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