Results 181 to 190 of about 28,078 (291)

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

open access: yesAdvanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu   +18 more
wiley   +1 more source

Facet‐dependent Heterogeneous Fenton Reaction Mechanisms on Hematite Nanoparticles for (Photo)catalytic Degradation of Organic Dyes

open access: yesAdvanced Science, EarlyView.
This study reveals how hematite crystal facets govern heterogeneous (photo)‐Fenton degradation of organic dyes. Facet‐dependent differences in H2O2 decomposition and reactive oxygen species generation are demonstrated, providing mechanistic insights that inform environmental strategies for water purification and pollutant remediation. Abstract Although
Ping Chen   +15 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Dynamic deep marine oxygenation during the Early and Middle Paleozoic. [PDF]

open access: yesSci Adv
Ostrander CM   +6 more
europepmc   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

open access: yesAdvanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang   +16 more
wiley   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang   +16 more
wiley   +1 more source

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